摘要
目的:探讨Pin1基因-842G/C位点多态性与散发性阿尔茨海默病(SAD)遗传易感性的关系。方法:应用聚合酶链反应限制性片段长度多态性(PCR-RELP)方法检测46例SAD患者和52名健康老年人的Pin1基因启动子多态性分布特征,并通过比值比(OR)分析基因与SAD之间的关系。结果:Pin1基因启动子多态性(842G/C)与SAD的发病风险不相关,C等位基因与G等位基因的OR=0.90(95%CI=0.37～2.19),而GG基因型与非GG型基因频率在SAD组与健康对照组比较差异无统计学意义(P>0.05)。结论:Pin1基因启动子-842G/C位点多态性可能并不是SAD发病的独立遗传危险因素,与SAD的发病无关。
Aim:To assess the correlation between Pin1 promoter-842G/C site polymorphisms and the genetic predisposition of sporadic Alzheimer s disease(SAD).Methods:The polymorphisms of Pinl promoter were determined in 46 SAD patients and 52 normal controls by PCR-RFLP method,and the relation between gene and SAD was analyzed by odds ratio(OR).Results:The promoter polymorphism(-842G/C) was not associated with SAD risk.The odds ratio for AD associated with the C allele vs G allele was 0.90 (95%CI=0.37～2.19),and the gen...
出处
《中国临床神经科学》
2009年第1期31-34,共4页
Chinese Journal of Clinical Neurosciences
