中西医结合方案对老年单纯收缩期高血压患者血管内皮功能及超敏C反应蛋白的影响

Effect of a Integrative Medical Regimen on Levels of Vascular Endothelial Function and Hypersensitive C-Reactive Protein in Elderly Patients with Isolated Systolic Hypertension

目的观察中西医结合方案(降压胶囊联合尼莫地平胶囊)对老年单纯收缩期高血压(elderly patients with isolated systolic hypertension,EISH)患者血压水平、中医症状、血管内皮功能及超敏C反应蛋白(hs-CRP)的影响。方法采用随机、双盲、对照的试验设计方法,将135例EISH患者随机分中西医结合组(简称结合组,给予降压胶囊联合尼莫地平胶囊)、中药组(给予降压胶囊+尼莫地平胶囊模拟药)及西药组(给予尼莫地平胶囊+降压胶囊模拟药)3组,疗程为4周。观察各组患者治前后血压水平及症状改善情况,血清一氧化氮(NO),血浆内皮素-1(ET-1)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)以及hs-CRP含量变化。结果与治疗前比较,各组收缩压水平显著降低,症状明显改善;治疗后各组血清(浆)NO、6-keto-PGF1α水平显著升高,ET-1、TXB2、hs-CRP水平显著降低(P<0.05,P<0.01);结合组降低收缩压的作用优于中药组或西药组(P<0.05),改善症状的作用优于西药组(P<0.01);结合组升高血清NO含量及降低血浆TXB2含量作用明显优于西药组(P<0.05)。结论中西医结合方案(降压胶囊联合尼莫地平)降压疗效显著,能够显著改善患者症状、血管内皮细胞功能并抑制炎症因子水平。

Objective To observe the effect of a integrative medical regimen(IMR),i.e.combined use of Jiangya Capsule(JYC) and Nimodipine(ND),on blood pressure,TCM clinical symptoms,and blood levels of vascular endothelial function and hypersensitive C-reactive protein(hs-CRP) in elderly patients with isolated systolic hypertension(EISH).MethodsAdopting randomized,double-blinded and controlled principle,a trial was conducted on 135 patients with EISH by randomized them into three groups,they were administered IMR(Group...