摘要
目的:观察电针对脊髓损伤(SCI)大鼠脑源性神经生长因子(BDNF)和神经功能活动的影响。方法:48只大鼠平均分为4组,采用改良的Allen’s造模方法建立大鼠SCI模型,电针对照组取"大椎"、"命门"和"夹脊穴"两组穴位交替电针治疗。7天后,通过取各组大鼠脊髓采用免疫组化法测定BDNF的表达水平和分析BBB行为记分法进行各组比较。结果:电针治疗组与甲基强的松龙组大鼠治疗后后肢运动功能改善,非常显著强于模型对照组(P<0.05),而显著差于空白对照组(P<0.01);两组BDNF阳性细胞数非常显著强于模型对照组和空白对照组(P<0.01),但组间没有显著性差异(P>0.05)。结论:电针治疗可明显增强SCI后BDNF的表达,促进SCI后神经的修复与再生,从而促进肢体功能的恢复。
Objective:To observation the effect on brain derivd neurotrophic factor(BDNF) and nerve function of spinal cord injury(SCI) rats by electroacupuncture.Methods:we set up SCI rat model by using improved Allen s model building method.48 rats were given into 4 groups,acupoint s alternative electroacupuncture treatment in Dazhui,Mingmen and Jiaji.7 days later,we abstracted rats spinal cord measured expressions of BDNF by immunohistochemistry method and analysizing BBB behavior scoring,to be compared with each g...
出处
《针灸临床杂志》
2009年第2期42-44,59,共4页
Journal of Clinical Acupuncture and Moxibustion
关键词
电针
脊髓损伤
神经生长因子
神经功能
Electroacupuncture
Spinal cord injury
Derivd neurotrophic factor
