外湿对正常小鼠过氧化与抗氧化影响的实验研究

Experimental Study of the Peroxidation-antioxidation Effect of Exopathic Dampness on Normal Mice

目的:探讨单纯环境因素─外湿对正常小鼠生物膜结构和功能改变的规律及其机制,从分子生物学角度揭示湿邪作用机体产生损伤的机理。方法:对模拟潮湿环境因素研制的外湿小鼠模型与正常小鼠在机体过氧化与抗氧化方面进行了比较研究。结果:外湿模型小鼠出现了体重的下降,丙二醛(malondialdehyde,MDA)和共轭双烯(conjugated dienes,CD)指标的升高,过氧化氢酶(Catalase,Cat)、超氧化物歧化酶(superoxid dismutase,SOD)和谷胱甘肽过氧化物酶(Glutathione peroxide,GSH-Px)指标的下降,说明外湿模型小鼠出现了脂质过氧化损伤和抗氧化酶活性的下降。结论:外湿可以导致机体脂质过氧化损伤和抗氧化酶活性下降。

This experiment is a comparative study on the mice with exopathic dampness modeled and normal mice on bodies change of peroxidation-antioxidation.The experiment aims to approach the laws and mechanisms of the change of the structure and function of the biomembrane in normal mice modeled through single circumstances factor:exopathic dampness,reveal that dampness damage organism after it invaded.The results show that the group of exopathic dampness have the decrease of body weight,the increase of the content...