摘要
目的通过组织学特性研究,探讨不同膜材料对植入式葡萄糖传感器组织相容性的影响因素,比较聚四氟乙烯(PTFE)、聚氨酯(PU)、聚氯乙烯(PVC)的组织相容性。方法SD大白鼠21只,随机分成3个相互对照组。分别将PTFE、PU、PVC按不同方法植入到大鼠背部两侧肌肉和皮下。分别于术后8,15,31d处死大鼠,进行组织切片光镜观察,并对形成纤维囊厚度、血管增生程度作统计分析。结果锐性植入比钝性植入形成的纤维囊厚度小(P<0.05),第2周纤维囊厚度增加较缓慢,而第3、4周增加显著,肌肉植入比皮下植入效果好(P<0.01)。PU、PVC对血管增生较好,但后者炎性反应最严重,纤维囊厚度最大。结论锐性植入PU的组织相容性较好。
Objective To investigate three membrane materials of implantable glucose sensor,here compare the histocompatibility of PTFE,PU,PVC and its influencing factors by histological examination.Methods The implanted materials were processed into disk shape with thickness of 0.5 mm and diameter of 6 mm.21 SD rats were selected and numbered randomly.The materials were implanted into the muscle on both side of spine and subcutaneously on one side,according to different implanted methods with different materials.The t...
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2009年第4期247-249,共3页
Journal of China Medical University
基金
辽宁省教育厅高校科研基金资助项目(20060950)
沈阳市科技局资助项目(1081225-1-00)
关键词
葡萄糖传感器
组织相容性
膜材料
纤维囊
glucose sensor
histocompatibility
membrane material
fibrous capsule
