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急性冠脉综合征患者血清MCP-1浓度和CCR2蛋白表达水平的变化 被引量：5

Change of serum MCP-1 level and CCR2 protein expression in isolated monocytes in patients with acute coronary syndrome
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摘要 目的:检测急性冠脉综合征(acute coronary syndrome,ACS)患者血中单核细胞趋化蛋白-1(monocyte chemotactic protein,MCP-1)和外周血单核细胞MCP-1受体CC趋化因子受体2(CC chemokine receptor 2,CCR2)表达水平的变化,探讨MCP-1和CCR2与ACS发生的关系。方法:收集ACS患者30例和健康体检者30例,分别应用ELISA法和流式细胞技术检测受试者血清MCP-1浓度和单核细胞上CCR2的表达水平。结果:ACS组血清MCP-1的水平明显高于健康对照组(P<0.05),ACS组外周血单核细胞CCR2蛋白表达水平明显高于健康对照组(P<0.01)。结论:ACS患者MCP-1浓度与CCR2表达水平均显著高于健康人,MCP-1和CCR2可能与ACS的发生发展有关。 Objective To investigate the change of serum MCP-1 level and CCR2 expression in isolated monocytes in patients with acute coronary syndrome(ACS)and its possible relationship with ACS pathogenesis.Methods Thirty ACS patients and 30 healthy controls were enrolled.Serum MCP-1 levels were determined by ELISA in all subjects.The protein expression of CCR2 in isolated monocytes was assessed by flow cytometry.Results Serum MCP-1 concentrations in ACS patients were higher than those in healthy controls(P<0.05)an...
作者 汪雁归 刘昭前 杨天(山仑)
机构地区 湖南省人民医院老干高知科 中南大学临床药理研究所 中南大学湘雅医院心内科
出处 《中南大学学报（医学版）》 CAS CSCD 北大核心 2009年第4期318-322,共5页 Journal of Central South University ：Medical Science
关键词 急性冠脉综合征 动脉粥样硬化 单核细胞趋化蛋白-1 CC趋化因子受体2 acute coronary syndrome atherosclerosis monocyte chemotactic protein-1 CC chemokine receptor 2
分类号 R541.4 [医药卫生—心血管疾病]
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同被引文献65

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引证文献5

二级引证文献20

中南大学学报（医学版）
2009年 第4期

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