辣椒碱-羟丙基-β-环糊精包合物制备鉴定及热力学稳定性研究

Preparation,identification and thermodynamic stability of capsaicin-hydroxypropyl-β-cyclodextrin inclusion compound

目的:制备及鉴定辣椒碱-HP-β-CD包合物,并考察辣椒碱和HP-β-CD之间的包合摩尔比及包合过程的热力学常数。方法:采用饱和水溶液法制备辣椒碱-HP-β-CD包合物,以差示扫描量热法(DSC)、X射线衍射法(XRD)和红外光谱法(IR)对包合物进行鉴定,通过表观溶解度法考察包合物中主客分子之间的包合摩尔比及包合过程的热力学常数。结果:25,35,45℃下辣椒碱和HP-β-CD能形成1:1摩尔比包合物,相溶解度图呈AL型。结论:辣椒碱-羟丙基-β-环糊精包合物能显著增大药物的溶解度。

Objective:To prepare and identify the capsaicin-hydroxypropyl-β-cyclodextrin(capsaicin-HP-β-CD)inclusion compound the mol ratio between capsaicin and HP-β-CD and the thermodynamic constants in inclusion were studied simultaneously.Method:The capsaicin-HP-β-CD inclusion compound was prepared with the method of saturation aqueous solution.Meanwhile,the inclusion compound was identified by differential scanning calorimetry methods(DSC),infrared spectrometry(IR),and X-ray diffraction(XRD),respectively.The mol r...