番石榴叶化学成分研究

Studies on chemical constituents of leaves of Psidium guajava

目的:研究番石榴Psidium guajava叶的化学成分。方法:利用葡聚糖凝胶Sephadex LH-20、硅胶和MPLC等色谱方法进行化合物的分离纯化,根据化合物的理化性质、波谱数据进行结构鉴定。结果:从番石榴叶中分离得到9个单体化合物,分别为:乌苏酸(ursolic acid,1),2α-羟基乌苏酸(2α-hydroxyursolic acid,2),2α-羟基齐墩果酸(2α-hydroxyoleanolic acid,3),番石榴苷(morin-3-O-α-L-arabopyranoside,4),槲皮素(quercetin,5),金丝桃苷(hyperin,6),杨梅素-3-O-β-D-葡萄糖(myricetin-3-O-β-D-glucopyranosid,7),quercetin-3-O-β-D-glucuronopyranoside(8),1-O-没食子酰基-β-D-葡萄糖(1-O-galloyl-β-D-glucose,9)。结论:化合物3,7~9为首次从该植物中分离得到。

Objective: To study the chemical constituents of the leaves of Psidium guajava.Method: The chemical constituents were isolated by column chromatography on silica gel,Sephadex LH-20 and MPLC.Their structures were elucidated on the basis of spectral analysis.Result: Nine compounds were isolated from this plant,and the structure of them were identified as ursolic acid(1),2α-hydroxyursolic acid(2),2α-hydroxyoleanolic acid(3),morin-3-O-α-L-arabopyranoside(4),quercetin(5),hyperin(6),myricetin-3-O-β-D-glucoside(7)...