无梗五加果化学成分的分离与鉴定

Isolation and identification of chemical constituents of fruits of Acanthopanax sessiliflorus

目的:对五加科五加属植物无梗五加Acanthopanax sessiliflorus果的化学成分进行分离与鉴定。方法:采用硅胶柱色谱,Sephadex LH-20柱色谱等方法对化学成分进行分离及纯化,根据化合物理化性质及波谱数据鉴定其结构。结果:分离得到9个化合物,oleanolic acid-3-O-6′-O-methyl-β-D-glucuronopyranoside(1),22-α-hydroxychiisanogenin(2),齐墩果酸-3-O-β-D-葡萄糖醛酸苷(momordin Ib3),齐墩果酸-3-O-β-D-葡萄糖苷(oleanolic acid-3-O-β-D-glucopyranoside4),齐墩果酸(oleanolicacid5),chiisanogenin(6),(-)-芝麻脂素[(-)-sesamin7],胡萝卜苷(daucosterol8),β-谷甾醇(β-sitosterol9)。结论:化合物1是首次从五加属植物中分离得到,化合物2~5是首次从该植物中分离得到。

Objective:To isolate and elucidate the chemical constituents of the fruits of Acanthopanax sessiliflorus.Method:Isolation and purification were carried out on the column chromatography of silica gel and Sephadex LH-20.Their structures were elucidated on basis of physicochemical properties and spectral data.Result:Nine compounds were isolated and identified as oleanolic acid-3-O-6′-O-methyl-β-D-glucuronopyranoside(1),22-α-hydroxychiisanogenin(2),oleanolic acid-3-O-β-D-glucuronopyranoside(3),oleanolic acid-3-...