斑蝥素及其衍生物的作用机制及临床应用

Clinical application and mechanism of Cantharidin and it's Ramification

斑蝥为芫菁科昆虫,南方大斑蝥Mylabrisphalerala Pallas或黄黑小斑蝥Mylabris cichoriiLinnaeus的干燥全虫,味辛、热,有大毒,在我国已经应用两千多年,是一种重要的昆虫类药物。现代药学研究表明其主要药用成分是斑蝥素,主要用于治疗肝癌、食管癌及胃癌。去甲斑蝥素(norcantharidin,NCTD)为斑蝥素的衍生物,是我国首先合成的具有较强抗肿瘤活性和独特升高白细胞作用的新型杭肿瘤药物。明显增强了抗癌效果,并显著降低了斑蝥素对人体的毒副作用。文章对国内外有关斑蝥素及其衍生物的作用机制和临床应用现状进行了综述。

Blister beetle or mylabris, pungent in flavor and toxic in nature, has been used for more than 2000 years as traditional Chinese medicine in China.Cantharidin, an active ingredient of the blister beetle, is an effective therapeutic agent against cancers of the liver, breast, esophagus, lung and intestine, etc.However, it is very toxic.Nocantharidin(NCTD), a derivative of cantharidin first synthesized in China, is a new anti-tumor-drug with strong anti-tumor activities and increases the number of while blood...