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用于基因传递系统控制释放的可生物降解高分子材料 被引量：4

BIODEGRADABLE POLYMERS FOR CONTROLLED RELEASE OF GENE DELIVERY SYSTEMS
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摘要 综述了用于基因传递系统控制释放的各类高分子材料包括天然高分子及其衍生物、合成高分子,并介绍了它们在基因治疗和组织工程领域中的应用. Gene therapy shows great promise to treat both acquired and inherited diseases.Numerous gene delivery systems based on viral and nonviral vectors have been developed to protect plasmid DNA and facilitate cell binding and internalization.Nevertheless,it is still a challenge to deliver DNA to target cell population and particular location by injection or systematic delivery due to the immune responses and DNA complex aggregation,degradation,and clearance from the tissue.Polymers loaded with gene or vector/gen...
作者 付慧莉 程巳雪 卓仁禧
机构地区 武汉大学化学与分子科学学院生物医用高分子材料教育部重点实验室
出处 《高分子学报》 SCIE CAS CSCD 北大核心 2009年第2期97-103,共7页 Acta Polymerica Sinica
关键词 可生物降解高分子 基因传递 组织工程 Biodegradable polymers Gene delivery Tissue engineering
分类号 R318.08 [医药卫生—生物医学工程]
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参考文献4

  • 1Swayam Prabha,Vinod Labhasetwar. Critical Determinants in PLGA/PLA Nanoparticle-Mediated Gene Expression[J] 2004,Pharmaceutical Research(2):354～364
  • 2Deborah J. Quick,Kristi S. Anseth. Gene Delivery in Tissue Engineering: A Photopolymer Platform to Coencapsulate Cells and Plasmid DNA[J] 2003,Pharmaceutical Research(11):1730～1737
  • 3Dan Luo,Kim Woodrow-Mumford,Nadya Belcheva,W. Mark Saltzman. Controlled DNA Delivery Systems[J] 1999,Pharmaceutical Research(8):1300～1308
  • 4Yilmaz Capan,Byung H. Woo,Sisay Gebrekidan,Shamim Ahmed,Patrick P. DeLuca. Preparation and Characterization of Poly (D,L-Lactide-Co-Glycolide) Microspheres for Controlled Release of Poly(L-Lysine) Complexed Plasmid DNA[J] 1999,Pharmaceutical Research(4):509～513

同被引文献26

  • 1李军,彭向前,张鉴.β-环糊精在中药制剂中的应用[J].中国药业,2005,14(6):26-27. 被引量：24
  • 2丁时踽,刘玲蓉,李学敏,张其清.以胶原为载体的蛋白药物体内释放和药代动力学的研究[J].中国生物医学工程学报,2005,24(6):775-779. 被引量：6
  • 3孔桦,孟洁,郭小天,杨子彬,许海燕.载药纳米羟基磷灰石材料的体外药物缓释研究[J].透析与人工器官,2005,16(3):12-15. 被引量：3
  • 4Berthold A,Cremer K, Kreuter J. Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs [J]. J Control Release, 1996,39 (1) :17- 25.
  • 5侯晓晖,刘白玲.药物控制释放用天然多糖载体的制备技术研究进展[J].广州化学,2007,32(3):51-58. 被引量：5
  • 6Won Y W, Lim K S, Kim Y H. IntraceUular organelle-targeted non- viral gene delivery systems [ J ]. J. Controlled Release, 2011, 152 (1): 99-109.
  • 7Liu Z, Zhang Z, Zhou C, et al. Hydrophobic modifications of cationic polymers for gene delivery[J]. Prog. Polym. Sci., 2010, 35(9) : 1144-1162.
  • 8Leung P S C, Dhirapong A0 Wu PY, et al. Gene therapy in autoimmune diseases: Challenges and opportunities [ J ]. Autoit'amunity Reviews, 2010, 9(3) - 170-174.
  • 9Kiddo Y, Jo J I, Tabata Y. A gene transfeetion for rat mesenchymal stromal cells in biodegradable gelatin scaffolds containing cationized polysaccharides[J]. Biomaterials, 2011, 32(3): 919-925.
  • 10Khan W, Hosseinkhani H, Ickowiez D, et al. Polysaccharide gene transfection agents[J]. Acta Biomater., 2012, 8(12) : 4224-4232.

引证文献4

二级引证文献11

高分子学报
2009年 第2期

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