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维持性血液透析患者血清OPN及ucMGP浓度与心血管钙化的关系 被引量：7

Association of Serum OPN and ucMGP with the Presence of Cardiovascular Calcification in MHD Patients
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摘要 目的探讨骨相关蛋白中骨桥蛋白(OPN)和非活性基质Gla蛋白(ucMGP)在维持性血液透析(MHD)患者合并动脉粥样硬化和心脏瓣膜钙化中的关系。方法55例MHD患者和22例正常对照者作为研究对象。采用ELISA法测定2组受试者血中OPN和ucMGP含量。测定颈动脉分叉处内-中膜厚度(IMT),用超声心动图检测心脏瓣膜是否出现钙化,分析骨相关蛋白水平与动脉粥样硬化和心脏瓣膜钙化之间的关系。结果MHD患者血中OPN及ucMGP显著升高。MGP在伴有颈动脉斑块和心脏瓣膜钙化组显著增高,其中OPN含量与颈动脉内膜厚度呈正相关关系(r=0.55,P<0.05)。结论MHD患者血中OPN及ucMGP的增高伴随动脉粥样硬化和心脏瓣膜钙化的发生,可作为心血管钙化程度的检测指标。 Objective To elucidate the association of osteopontin(OPN)and the circulating inactive form of matrix Gla protein(ucMGP)with the presence of cardiovascular calcification in maintenance hemodialysis(MHD)patients.Methods Serum OPN and ucMGP in 55 MHD patients and 22 health subjects at matching age were measured using ELISA.The intimal and medial thicknesses(IMT)in carotid artery were measured by doppler ultrasonography and the cardiac valve calcification by colour doppler ultrasonography.Results The levels of...
作者 李国刚 刘惠兰 张坤英 段晓峰
机构地区 首都医科大学附属复兴医院肾内科
出处 《首都医科大学学报》 CAS 北大核心 2009年第2期130-132,共3页 Journal of Capital Medical University
基金 北京西城区科技计划(2008018)资助项目~~
关键词 骨桥蛋白 无活性基质Gla蛋白 动脉粥样硬化 心脏瓣膜钙化 血液透析 osteopontin ucMGP atherosclerosis cardic valvular calcification hemodialysis
分类号 R692.5 [医药卫生—泌尿科学]
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首都医科大学学报
2009年 第2期

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