基于MRI的多发性硬化患者和阿尔茨海默病患者纹理特征对比

Texture Characteristic Comparison between Patients with Multiple Sclerosis and Those with Alzheimer 's Disease Based on MR Imaging

目的比较多发性硬化(multiple sclerosis,MS)患者与阿尔茨海默病(Alzheimer's disease,AD)患者脑部常规MRI的纹理特征。方法选取MS和AD患者以及健康对照者各13例,提取其MR矢状位T1加权图像的大脑实质作为感兴趣区,映射成灰度共生矩阵,然后提取能量、熵、对比度和逆差距4个纹理特征参数,比较上述3组之间的纹理特征差异是否有统计学意义。结果3组的能量、熵及逆差距纹理特征两两之间的差异有统计学意义(P<0.05);在对比度上,MS组和对照组、AD组与对照组的差异有统计学意义(P<0.05),而MS组与AD组之间的差异无统计学意义(P=0.332)。结论MS患者MRI的纹理特征与健康对照组显著不同,表明纹理分析方法有可能揭示MS患者脑实质的病理改变,有助于辅助疾病的早期诊断;同时MS患者与AD患者的纹理特征差异具有统计学意义,表明纹理分析方法有可能揭示MS和AD等其他脑实质病变的病理差异,有助于MS与AD等疾病的鉴别诊断。以上结论还需扩大样本量并采用多种方法进一步证实。

Objective Multiple sclerosis(MS)is a chronic inflammatory disease of the central nervous system,which leads to severe progressive neurological dysfunction.Alzheimer s disease(AD)is a severe neurodegenerative disease of the central nervous system.The previous researches shown that there were significant differences between MRI texture characteristics of MS and normal control(NC).To compare texture characteristics of MS and other cerebral parenchyma diseases,the differences of cerebral parenchyma texture char...