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2型糖尿病大鼠模型血管钙化及相关因素分析 被引量：3

Vascular Calcification in Rat Models of Type 2 Diabetic Nephropathy
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摘要 目的观察2型糖尿病大鼠模型血管钙化发生情况并分析其危险因素。方法用高脂肪、高热量饲料加腹腔注射链脲佐菌素(STZ)建立大鼠糖尿病模型,对照组予常规饲料。通过VonKossa染色和原子分光光度计方法观察2组大鼠血管钙化情况,同时检测血糖、胰岛素、尿白蛋白和肌酐清除率(Ccr)等变化。结果血糖、胰岛素和腹腔注射葡萄糖糖耐量试验等结果证实造模成功。2组大鼠胸主动脉HE、VonKossa染色未见明显钙盐沉积,原子分光光度计定量检测显示实验组大鼠血管钙含量明显高于对照组,差异有统计学意义(P<0.01)。相关分析未发现体质量、血糖、血胰岛素、尿白蛋白和Ccr与血管钙含量相关。结论用高脂肪、高热量饲料和腹腔注射STZ建立的糖尿病大鼠模型的胸主动脉钙含量明显增加,其血管钙化的原因和机制有待于进一步研究。 Objective To investigate the vascular calcification and its risk factors in type 2 diabetic rat models.Methods Models of type 2 diabetes were established in rats by high-energy diet and an intraperitoneal injection of streptozocin(STZ,30 mg/kg).The rats in control group were fed with regular diet.Calcification of rat aortas were indentified by Von Kossa staining and atomic absorptiometry.Fasting blood glucose,insulin,24 h urine albumin excretion and creatinine clearance rate were monitored.Results The rats ...
作者 王英 刘惠兰 安娜
机构地区 首都医科大学附属复兴医院肾内科
出处 《首都医科大学学报》 CAS 北大核心 2009年第2期227-230,共4页 Journal of Capital Medical University
关键词 糖尿病 血管钙化 危险因素 diabetes angiosteosis risk factor
分类号 R587.1 [医药卫生—内分泌]
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参考文献2

  • 1M. Inaba,S. Okuno,Y. Imanishi,S. Yamada,A. Shioi,T. Yamakawa,E. Ishimura,Y. Nishizawa. Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients[J] 2006,Osteoporosis International(10):1506～1513
  • 2Dr. J. E. Everhart,D. J. Pettitt,W. C. Knowler,F. A. Rose,P. H. Bennett. Medial arterial calcification and its association with mortality and complications of diabetes[J] 1988,Diabetologia(1):16～23

同被引文献27

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首都医科大学学报
2009年 第2期

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