石膏及白虎汤清热泻火功效的实验研究

Study on Effects of Clearing Away Heat and Purging Fire from Gypsum and Baihu Decoction

目的研究石膏的清热泻火药理作用。方法以干酵母及2,4-二硝基苯酚复制大鼠发热模型,对石膏、白虎汤、去石膏白虎汤,以及煅石膏和CaSO4?2H2O分别代替石膏入白虎汤的退热作用进行药效学观察,以证实石膏及白虎汤的清热功效;以伊文思蓝为指示剂,根据伊文思蓝在小肠内的推进率,观察单味石膏对小鼠肠蠕动的影响,以证实石膏促进肠蠕动的作用。结果对干酵母及2,4-二硝基苯酚所致大鼠的发热,白虎汤有显著退热作用,;去石膏的白虎汤退热作用不明显,单味石膏、煅石膏或CaSO4?2H2O入方剂均无退热作用。单味石膏具有明显的促进小鼠肠蠕动的作用。结论石膏具有清热的功效,在复方中效果显著。单味石膏具有促进肠蠕动的作用。

Objective To study clearing away heat and purging fire effects of Gypsum and Baihu Decoction. Methods Inducing pyrexia models by injecting yeast and 2,4 - dinitrophenol in rats to observe cleaing away heat effects in gypsum group(GG), Baihu Decoction group(BG), Baihu Decoction without gypsum group(WGG),anhydrite adding into Baihu Decoction instead of gypsum group(AIG) and CaSO4-2H2O adding into Baihu Decoction instead of gypsum group (CIG).Taking Evans blue as indicator to obverve enhancing intestina parva ...