环氧化物酶-2在腺性膀胱炎中的表达及其与复发的关系

Expression of COX-2 in Cystitis Glandularis and Its Implication to Relapse

目的探讨环氧化物酶-2(COX-2)在腺性膀胱炎中的表达及其与复发的关系。方法应用免疫组织化学SP法,检测40例腺性膀胱炎无复发患者和25例腺性膀胱炎复发患者病变组织中COX-2的表达。以10例正常膀胱黏膜组织作为对照。结果10例正常膀胱黏膜组织中COX-2呈阴性表达,40例腺性膀胱炎无复发患者病变组织中COX-2阳性表达率为35.0%,25例腺性膀胱炎复发患者病变组织中COX-2阳性表达率为64.0%,3组膀胱组织中COX-2的阳性表达率间差别有统计学意义(P<0.05)。复发患者病变组织中COX-2的表达强度与对照组比较,差别有统计学意义(P<0.05)。结论腺性膀胱炎组织中COX-2的表达较正常膀胱组织中增高,其中复发者的COX-2阳性表达率及表达强度均明显增高,提示临床上行COX-2的检测对判断腺性膀胱炎患者的预后有一定指导意义。

Objective To explore the expression of cyclooxygenase-2(COX-2)protein and its clinical implication to relapse of disease in cystitis glandularis.Methods The immunohistochemistry-streptavdin-peroxidase(SP)method was taken to detect the expression of COX-2 protein in focal tissues of 40 cystitis glandularis patients without relapse and 25 cystitis glandularis patients with relapse,and with normal bladder mucosa tissues of 10 subjects as the controls.Results The expression of COX-2 protein in normal bladder mu...