胰岛素联合中药治疗阴虚燥热型初诊2型糖尿病的临床疗效观察

Insulin Combined with Traditional Chinese Medicine in Newly-diagnosed Type 2 Diabetes with Extreme Heat due to Yin Deficiency

目的观察中药联合胰岛素治疗阴虚燥热型初诊2型糖尿病(T2DM)的效果。方法48例阴虚燥热型初诊T2DM患者随机分为胰岛素治疗组(胰岛素组)及中药联合胰岛素治疗组(联合治疗组),胰岛素组单纯给予胰岛素治疗,联合治疗组加用自拟降糖方治疗。结果联合治疗组治疗后患者的血糖(FBG)、葡萄糖曲线下面积(AUCG)、胰岛B细胞功能指数(Homa-B)、胰岛素抵抗指数(Homa-IR)、胰岛素曲线下面积(AUCI)、30min内C肽曲线下面积(AUCCP30)、症状总评分、主要症状评分〔分别为:(5·6±1·3)mmol/L、(39±7)、(138±40)、(59±20)、(16±5)、(1·9±0·9)、(15·6±2·1)分、(5·4±1·5)分〕较治疗前〔分别为:(13·9±3·1)mmol/L、(61±18)、(14±4)、(35±11)、(8±4)、(5·2±1·2)、(32·8±8·3)分、(21·6±4·6)分〕差异均有统计学意义(P<0·05)。治疗后联合治疗组Homa-B、主要症状评分〔(138±40)、(5·4±1·5)分〕与胰岛素组〔(112±46)、(8·4±2·4)分〕比较差异均有统计学意义(P<0·05)。结论阴虚燥热型初诊T2DM患者,在短期胰岛素治疗基础上,联合中药治疗,可进一步改善胰岛素抵抗,改善临床症状。

Objectives To explore the effects of short-term insulin intensive treatment with Chinese traditional medicine(CTM) on newly-diagnosed type 2 diabetes mellitus(T2DM)with extreme heat due to yin deficiency.Methods Forty-eight newly-diagnosed T2DM patients with extreme heat due to yin deficiency were randomized into insulin group(receiving insulin treatment only) and combination group(receiving treatment of insulin combined with CTM).Results In combination group,significant difference was noted in FBG,AUCG,Hom...