青霉素萃取体系中第三相的生成与机理研究

FORMING MECHANISM OF THE THIRD PHASE IN THE PENCILLIN EXTRACTION SYSTEMS

在青霉素／ＣＴＡＢ／水／乙酸丁酯的模拟萃取体系中，当青霉素的浓度为 ０．０４２ｍｏｌ／Ｌ、 ＣＴＡＢ浓度小于 ０．０５４ ｍｏｌ／Ｌ时体系有第三相产生：当ＣＴＡＢ浓度大于０．０５４ ｍｏｌ／Ｌ时第三相消失，体系恢复为两相，此时下相有严重的乳光现象。第三相表面张力、粘度受ＣＴＡＢ和青霉素的浓度变化影响不大，而第三相的电导值受ＣＴＡＢ的浓度影响较大，组分分析证明第三相有大量的水和乙酸丁酯互溶，其中青霉素与ＣＴＡＢ的浓度比接近１：１。第三相通过冷冻蚀刻透射电镜观察，发现比较典型的片层状结构。对第三相的形成原因做了部分解释。

In the extraction systems of Penicillin G model with aqueous solutions of cetyltrimetyl ammonium bromide (CTAB) as aqueous phase and butyl acetate as organic phase, third phase was found at certain conditions. The third was phase formed at the concentration of CTAB lower 0.054 mol/L and at the fixed concentration of Pencillin G 0.042mol/L. The surface tension and viscosity was affected little by increasing the concentration change of CTAB and Pencillin G. Conductivity was affected by increasing the concen...