眼镜蛇毒素抗类风湿性关节炎实验研究

Anti inflammatory action of cobra(Naja naja)venom

目的 :观察眼镜蛇 (Najanaja)毒素的抗炎作用。方法 :采用大鼠佐剂性关节炎和大鼠棉球肉芽肿模型。结果 :眼镜蛇毒素对佐剂性关节炎模型大鼠的踝关节肿胀程度无明显影响 ,但使大鼠棉球肉芽肿重量显著减轻 (P <0 0 5 )。结论 :眼镜蛇毒素对关节滑膜增生可能有一定保护或逆转功能。

ORJECTIVE:To observe the antiinflammatory action of cobra(Naja naja)venom.METHODS:Cobra venom was administered subcutaneously at doses of 2μg/kg,10μg/kg and 50μg/kg for 20 days after Freund complete adjuvant infection and intragastrically at dose of 25mg/kg for 7 days after cotton pellets planted in rats.RESULTS:Cobra venom had no effect on the edema induced by adjuvant,but inhibited markedly granuloma information caused by cotton pellets in rats.CONCLUSION:Cobra venom may be effective on synovitis.