匹罗卡品致鼠慢性颞叶癫痫模型

The Pilocarpine Model of Chronic Temporal Lobe Epilepsy in Rats

目的 :确定匹罗卡品点燃鼠持续性癫痫后的急性和慢性行为改变及组织学影响。方法 :癫痫持续状态后 ,对存活鼠以影像监控系统连续监测 12 0 d,2 4h/ d。以光镜观察其脑部损伤。结果 :首次自发性复发性癫痫在癫痫持续状态后 4～ 42 d内出现 ,其平均“平静期”为 ( 14.5± 3.6 ) d。在慢性阶段 ,自发性复发性癫痫以每周每只鼠 2～ 4次的发作频率出现 ,其脑部损伤主要位于颞叶。结论 :匹罗卡品致鼠癫痫持续状态所造成的脑颞叶损伤可能是形成慢性癫痫的基础 ,其机制在病因学上与人类癫痫的某些特征相似。

Objective:To characterize the acute and chronic behavioral and histologic effects of sustained seizures induced by pilocarpine in rats. Methods:After status epilepticus, the surviving animals were continuously monitored during 24 h for 120 days,using a video system, then we examined the morphology of the brains by light microscopy. Results:First spontaneous recurrent seizures accurred between 4 and 42 days after status epilepticus. The mean “seizure silent period” lasted for(14.5±3.6)days. During the chroni...