老年消化性溃疡患者血浆内皮素、降钙素基因相关肽、一氧化氮变化及其意义

Changes of Plasma Endothelin, Calcitonin Gene Related Protein,and Serum Nitric Oxide in Senior Patients With Peptic Ulcer

目的 :观察血浆内皮素 ( ET)、降钙素基因相关肽 ( CGRP)和一氧化氮 ( NO)与老年消化性溃疡的关系。方法 :胃镜证实的老年活动期消化性溃疡患者 38例 (男 2 9例 ,女 9例 ) ,平均年龄 6 5 .8岁。健康老年人 40例 (男 30例 ,女 10例 ) ,平均年龄 6 6 .1岁。采用放射免疫分析法检测血浆 ET、CGRP。比色法检测血清 NO。结果 :老年消化性溃疡组血浆 (清 ) ET、CGPR和 NO浓度分别为 ( 78.31± 2 9.5 6 ) ng/ L、( 30 .14± 18.73) ng/ L 和 ( 3.87± 2 .7) μmol/L;正常对照组分别为 ( 5 4.16± 6 .42 ) ng/ L、( 45 .38± 14.5 6 ) ng/ L 和 ( 5 .92± 3.44 ) μmol/ L。两组比较 ET浓度明显升高 ( P <0 .0 1) ,CGRP、NO浓度明显降低 ( P <0 .0 1,P <0 .0 5 )。结论 :老年消化性溃疡患者 ET升高 ,可能与溃疡的发病有关 ;CGRP水平降低 ,可能是溃疡病发生的原因之一 ;NO水平降低 ,提示在溃疡的形成和愈合过程中存在 NO的粘膜保护作用不足。

Objective:Our purpose was to study the relationship between peptic ulcer in senior patients and one of following:the concentration of plasma endothelin(ET),plasma calcitonin gene related protein(CGRP),serum nitric oxide(NO). Methods:We randomly selected 38 senior patients (29 men and 9 women) with peptic ulcer at active stage who underwent gastric endoscopy. We also had a control of 30 men and 10 women. Plasma ET,CGRP were measured with radioimmunoassay. Serum NO was measured with colorimetric analysis. Res...