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双特异性单抗异聚体促进红细胞清除循环致病原 被引量：3

Bispecific monoclonal antibody heteropolymer bound to erythrocyte facilitate pathogens clearance from circulation
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摘要 论述了灵长类红细胞抗 - CR1单抗 (抗 - CR1m Ab)与抗致病原单抗 (抗细菌或病毒 m Ab) ,经过硫醚或生物素基化并经抗生蛋白链菌素 (SA)连接 ,形成双特异性单抗异聚体 (HP)。此 HP不但与灵长类红细胞上成簇分布的 CR1分子特异性结合 ,同时也与致病原单抗特异性地结合 ,从而使红细胞与致病原间接结合形成复合体 (E- HP- Ag)。此复合体一旦形成 ,绝大部分循环中的致病原 (>90 % )可被迅速清除 ,在肝脏中迅速销毁 ,同时伴有 ECR1的永久性损失 ,显示出红细胞强大的免疫调理功能。在国外已形成目前治疗血源感染性疾病 (特别是缺乏有效药物治疗的病毒性感染疾病 )最有前途的研究领域之一。
作者 王海滨 郭峰
机构地区 第二军医大学长海医院免疫室
出处 《免疫学杂志》 CAS CSCD 北大核心 2000年第z1期96-98,共3页 Immunological Journal
关键词 红细胞补体受体Ⅰ型(ECR1) 异聚体 致病原
分类号 R392. [医药卫生—免疫学]
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参考文献10

  • 1[1]TAYLOR RP , SUTHERLAND WM , REIST CJ,et al. Using of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes :a potential therapeutic treatmen[J]. Proc Natl Acad Sci USA.1991,88(8):3 305-3 309.
  • 2[2]TAYLOR RP,SUTHERLAND WM,MARTIN EN, et al. Bispecific monoclonal antibody complexes bound to primate erythrocyte complement receptor 1 facilitate virus clearance in a monkey model [J]. J Immunol,1997,158(2) :842-850.
  • 3[3]KUHN SE,NARDIN A,KLEBBA PE,et al. Escherichia coli bound to the primate erythrocyte complement receptor via bispecific monoclonal antibodies are transferred to and phagocytosed by human monocytes in an in vitro model[J]. J Immumol, 1998,160( 11 ): 5 088-5 097.
  • 4[4]NARDIN A,SUTHERLAND WM,HEVEY M,et al. Quantitative studies of heteropolymer-mediated binding of inactivated Marburg virus to the complement receptor on primate erythrocytes[J]. J Immuol Methods, 1998,211(1-2) :21-31.
  • 5[5]TAYLOR RP,FERGUSON PJ,MARTIN EN,et al. Immune complexes bound to the primate erythocyte complement recepror (CR1) via anti CR1 mAbs are cleared simultaneously with loss of in a concerted reaction in a rhesus monkey model [J]. Clin Immunol Immuopath, 1997,82 ( 1 ): 49-59.
  • 6[6]TAYLOR RP , NARDIN A , SUTHERLAND WM,et al. Clearance of blood-bome pathogens mediated through bispecific monoclonal antibodies bound to the primate erythrocyte complement receptor [J]. Cancer Immunol Immunother, 1997,45(3-4): 152-155.
  • 7[7]TAYLOR RP,MARTIN EN,REINAGEL ML,et al. Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model [J]. J Immunol,1997,159(8):4 035-4 044.
  • 8[8]REINAGEL ML,GEZEN M,FERGUSON PJ,et al. He primate erythrocyte complement receptor (CR 1 ) as a privileged site:binding of immunoglobulin G to erythrocyte CR1 does not target erythrocytes for phagocytosis[J]. Blood, 1997,89( 3): 1 068-1 077.
  • 9[9]FERGUSON PJ,MARTIN EN,GREENE KL,et al. Antigen-based heteropolymers facilitate, via primate erythrocyte complement receptor type 1, rapid erythrocyte binding of an autoantibody and its clearance from the circulation in rhesus monkeys [J]. J Immunol, 1995,155( 1 ): 339-347.
  • 10[10]TAYLOR RP, FERGUSON PJ. Primate erythrocyte (E)complement receptor (CR1) as an anchor site for bispecificbased therapies to clear pathogens or auto-antibodies safely from the circulation [J]. J Hematother, 1995,4 (5): 357-362.

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免疫学杂志
2000年 第z1期

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