幽门螺杆菌感染与胃癌关系的Meta分析

Meta-analysis of helicobacter pylori infection and gastric carcinoma

目的 确定幽门螺杆菌感染与胃癌的关系 ,为探讨胃癌的病因和防治措施提供依据。方法 用计算机辅以手工检索原始文献 ,用Meta -分析方法中的随机效应模型 (D -L法 )对检索到的国内 2 3篇病例对照研究进行综合定量分析 ,求得综合比值比 (OR) ,并对该综合分析结果及可能出现的偏倚进行讨论。结果 幽门螺杆菌感染与胃癌的发生有明显的联系 (OR =2 .5 9,95 %CI:1.82～ 3 .6 8) ;其中与胃非贲门部癌、腺癌的联系具有统计学意义 ,其合并OR(95 %CI)依次为 3.35 (1.30～ 8.5 9)、3 .94(2 .41～ 6 .42 ) ;与胃贲门部癌及非腺癌的联系无统计学意义 (OR =1.38,95 %CI :0 .91～ 2 .0 8;OR =1.5 5 ,95 %CI :0 .99～ 2 .44 )。结论 幽门螺杆菌感染与胃癌的发生尤其是非贲门部癌。

Objective To determine the association of helicobacter pylori(Hp) infection with gastric carcinoma and to provide evidence for the etiology and preventive measures of gastric carcinoma. Methods Used Meta-analysis (D-L ways), the data of 23 indexed case -control study reports were studied, and calculated the combined odds ratio(OR). Results Hp infection had significant association with gastric carcinoma(OR=2.59,95% CI:1.82～3.68), and was especially statistically difference between the Hp infection and non-cardiac carcinoma and gastric adenocarcinoma, the combined OR(95% CI)was 3.35(1.30～8.59) and 3.94(2.41～6.42);but Hp infection had no statistical significance with cardiac carcinoma and no-adenocarcinoma(OR=1.38,95%CI:0.91～2.08) and (OR=1.55,95%CI:0.99～2.44) Conclusion A significant association exists between Hp infection and gastric carcinoma, especially in the case of non-cardiac gastric carcinoma and adenocarcinoma.