硒剂对阿霉素所致肾病的防护作用

Protective effects of selenium on nephropathy induced by adriamycin

目的 探讨阿霉素所致肾病的防护方法。方法 采用全自动生化分析仪检测阿霉素所致肾病大鼠尿蛋白含量、血清白蛋白 (ALB)、丙氨酸转氨酶 (ALT)、门冬氨酸转氨酶 (AST)、肌酐 (Cr)、胆固醇(CHOL)含量的变化 ;采用紫外分光光度法检测过氧化氢酶 (CAT)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)的活性及过氧化脂质 (LPO)含量变化。结果 在应用阿霉素的同时或预先应用硒剂 ,可明显减轻大鼠肝脏、肾脏受损伤程度 ;显著提高血中CAT、SOD、GSH -Px的活性 ,使LPO生成明显下降 ,有效减轻阿霉素的毒性作用 ;一旦大鼠阿霉素肾病形成再行补硒 ,则短期内不可逆转。结论 硒对阿霉素所致肾病具有防护作用。

Objective To research the protective method of nephropathy results from adriamycin. Method The contents of urine protein ,and the sernm albumin(ALB), alanine transaminase (ALT), aspartate transaminase(AST), creatine(Cr) and cholesterin (CHOL) by biochemisty autoanalysiser and the activities and quality of lipid peroxide(LPO), serum catalase(CAT), superoxide dismutase(SOD) and glutathionase peroxide(GSH-Px) by the ultraviolet spectrophotometry were observed in nephrotic rats indueed by atriamycin. Results When selenium (sc) were supplied along or with in adrance adviamycin, it can obviously decrease the damage of rat’s liver and kidney, it also obviously increase the activities of CAT,SOD,GSH-Px and decrease LPO contents, and alleviate the toxic effects of adriamycin. Once the nephropathy was developed, the nephropathy didn’t reversd in short time.Conclusion Se possesses the protective effects on nephropathy results from adriamycin.