盐酸法舒地尔、依达拉奉联合治疗急性脑梗死的临床研究

Clinical Analysis of Treatment on Acute Cerebral Infarction with Hydrochloric Fasudil and Edaravone

目的:评价盐酸法舒地尔、依达拉奉联合治疗急性脑梗死的疗效及安全性。方法:选择符合入选标准的112例急性脑梗死,随机分为治疗组(n=50)和对照组(n=62),对照组应用依达拉奉治疗,治疗组应用依达拉奉和盐酸法舒地尔联合治疗,评价两组治疗前及治疗后3 d、7 d、14 d、28 d的神经功能缺损评分。结果:治疗组与对照组经治疗后ESS评分均有改善(P<0.05),治疗组较对照组疗效更显著(P<0.05),两组均无严重不良反应。结论:盐酸法舒地尔、依达拉奉联合治疗急性脑梗死比单用依达拉奉治疗急性脑梗死更有效改善神经功能缺损,且较安全。

Objective:To evaluate the efficacy and safety of the combined treatment of hydrochloric fasudil and edaravon.Methods:The 112 cases of acute cerebral infarction with the selected criteria were radomly divided into treatment group(n=50) and control group(n=62).The control group were treated with edaravone,while the teatment group were treated with hydrochloric fasudil and edaravone.The scores of neurologic impairment were recorded before the treatment and 3 days,7 days,14 days,28 days after the treatment.Results:The score by ESS in the two groups were increased after treatment.The efficacy of the treatment group were better than that of the control group.No serious aderverse reactions were oberserved in the two groups.Conclusion:The combined therapy of acute cerebral infarction with hydrochloric fasudil and edaravone is more effective than that with edaravone only.The combined therapy of acute cerebral infarction is safe.