抗纤溶剂在急性非静脉曲张性上消化道出血中的疗效评价

Evaluation of Anti-fibrinolysis Agents in Acute Non-variceal Upper Gastrointestinal Bleeding

目的:探讨静脉使用抗纤溶剂对急性非静脉曲张性上消化道出血的疗效及心脑血管并发症。方法:急性非静脉曲张性上消化道出血患者216例随机分为对照组(A组,n=106)和观察组(B组,n=110),对照组仅用洛赛克治疗,观察组加用抗纤溶药氨甲环酸:比较两组止血疗效及心脑血管并发症发生率。结果:两组止血疗效无明显差别(P>0.05);A组心绞痛、短暂脑缺血发作(TIA)发生率明显低于B组(P<0.05)。结论:静脉使用抗纤溶药对非静脉曲张性上消化道出血无确切疗效,但可增加心脑血管并发症。

Objective: To explore effects of anti-fibrinolysis agents in acute non-variceal upper gastrointestinal bleeding and related complications of cardio-cerebrovascular. Methods: 216 patients with acute non-variceal upper gastrointestinal bleeding were put in the study, 106 cases (Group A) just used Losec by intravenous drip and the other 110 cases (Group B) were treated with anti-fibrinolysis agents (Tranexamic acid) combined with Losec by intravenous drip. The effect and complications were compared between the two groups. Results: There was no significant difference (P > 0.05)between group A and group B on effect, but the incidence of angina or transient ischemic attack (TIA) in group A was lower than Group B (P <0.05). Conclusions: There is no exact effect in using anti-fibrinolysis agents by intravenous drip for non-variceal upper gastrointestinal bleeding, that may increases the risk of cardio-cerebrovascular complications.