福建泉州地区近15年急性胰腺炎病因学变化趋势

Analysis on Etiology of Acute Pancreatitis in Past 15 Years in Quanzhou District

目的观察泉州地区近15年间急性胰腺炎(AP)患者的住院构成比和病因谱的变化。方法总结分析福建医科大学附属第二医院1991—2005年450例AP住院患者的临床资料,将15年资料按每5年为一年度段进行统计分析。结果1991—1995年、1996—2000年、2001—2005年3个年度段AP患者绝对例数逐年增多,AP患者占同期内外科住院总例数构成比间差别有统计学意义(P<0.05)。3个年度段共收治450例AP患者,男241例,女209例,男女比例为1.15:1。3个年度段中胆源性、特发性、高脂血症性和酒精性AP患者的男女构成间差别均无统计学意义(P>0.05)。3个年度段男性患者的平均年龄间差别无统计学意义(P>0.05);3个年度段女性患者的平均年龄间差别有统计学意义(P<0.05)。结论AP发病例数逐年增多,胆源性和特发性AP患者中女性多于男性,高脂血症性和酒精性AP患者中男性多于女性。胆道疾病仍为AP的主要病因,余为高脂血症等因素。

Objective To investigate the changes in constituent ratio and etiologies of acute pancreatitis(AP) in different time periods in Quanzhou District.Methods Analyses were performed on clinical data of 450 AP patients hospitalized in 2nd Affiliated Hospital of Fujian Medical University from 1991 to 2005.Data were divided into group A(1991-1995),group B(1996-2000),group C(2001-2005),to perform statistical analyses.Results The absolute number of AP patients increased year by year.The ratio of male to female was 1.15:1.Groups A,B,C accounted for 0.15%,0.33% and 0.46%,respectively,out of the total cases hospitalized in departments of surgery and medicine during the corresponding time periods,the difference was significant(P<0.05).The incidences of biliary tract diseases of groups A,B,C were 40.00%,42.75%,39.77%,respectively(P>0.05);those of idiopathic pancreatitis were 38.33%,27.48%,17.37%,respectively(P>0.05);those of hyperlipidemia were 3.33%,9.22%,21.62%,respectively(P>0.05).Conclusion The number of AP patients is increasing year by year.There are more females than males in biliagenic or idiopathic AP patients,and more males in hyperlipidemia or alcohol-induced AP.Biliary tract diseases remain the major causes of AP.