还原型谷胱甘肽联合前列腺素E_1治疗慢性乙型肝炎疗效分析

Effects of the Combined Therapy of Reduced Glutathione and Prostaglandin E_1 on Chronic Hepatitis B

目的探讨还原型谷胱甘肽(GSH)联合前列腺素E1治疗慢性乙型肝炎(慢性乙肝)患者的疗效及对患者体内氧化损伤的影响。方法将我院2007年1月—2009年1月收治的62例慢性乙肝患者随机分为观察组(31例)和对照组(31例),在支持治疗的基础上,对照组给予GSH1200mg加入100ml0.9%氯化钠溶液中静脉滴注,1次/d;观察组在对照组治疗的基础上,给予前列腺素E120μg加入100ml0.9%氯化钠溶液中静脉滴注,1次/d。均治疗4周。比较两组患者治疗后的临床疗效及治疗前后血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平。结果治疗后治疗组显效22例,有效7例,无效2例;对照组显效17例,有效5例,无效9例,两组患者疗效间差异有统计学意义(u=1.99,P<0.05)。治疗前对照组患者血清SOD、GSH-Px、MDA水平〔分别为(106±18)μU/L、(57.8±23.4)U/L和(9.4±1.3)μmol/L〕与观察组〔分别为(103±13)μU/L、(57.4±21.4)U/L和(9.4±1.3)μmol/L〕比较,差异均无统计学意义(P>0.05);治疗后对照组患者血清SOD、GSH-Px、MDA水平〔分别为(173±13)μU/L、(89.4±15.8)U/L和(7.9±3.5)μmol/L〕与观察组〔分别为(199±11)μU/L、(103.2±14.3)U/L和(5.6±2.4)μmol/L〕比较,差异均有统计学意义(P<0.05)。结论GSH联合前列腺素E1治疗慢性乙肝患者的疗效优于单用GSH治疗者,联合治疗能改善慢性乙肝患者体内的氧化-抗氧化损伤平衡的紊乱。

Objective To investigate the effects of the combined therapy of reduced glutathione(GSH)and prostaglandin E1 in patients with chronic viral hepatitis B(CHB)and on the oxidative impairment in the body.Methods From January 2007 to January 2009 62 CHB patients were enrolled and randomly divided as trial group(n=31)and control group(n=31).The patients in the control group were treated with GSH(1 200 mg in 0.9% sodium chloride solution 100 ml)based on the supporting therapy;while those in the trial group with additional prostaglandin E1(20 μg in 0.9% sodium chloride solution 100 ml)for four weeks.The clinical effects,and serum levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)andmalondialdehyde(MDA)were observed,and the results between the two groups were compared.Results After treatment,there were in the trial group 22 case with a remarkable effect,7 cases with an effect,and 2 cases with no response;while in the control group 17 cases,5 cases,and 9 cases respectively,with a significant difference(u=1.99,P<0.05).Before treatment,the levels of serum SOD,GSH-Px and MDA in the trial group were(106±18)μU/L,(57.8±23.4)U/L and(9.4±1.3)μmol/L respectively;and those in the control group were(103±13)μU /L,(57.4±21.4)U/L and(9.4±1.3)μmol/L respectively,with no significant difference(P>0.05).After treatment,the levels of serum SOD,GSH-Px and MDA in the trial group were(173±13)μU/L,(89.4±15.8)U/L and(7.9±3.5)μmol/L respectively;and those in the control group were(199±11)μU/L,(103.2±14.3)U/L and(5.6±2.4)μmol/L respectively,with significant differences(P<0.05).Conclusion The combined therapy of GSH and prostaglandin E1 for CHB patients is of higher effect than GSH only,it can correct oxidants-antioxidants imbalance in the body of CHB patient.