8-异前列腺素F2α与阻塞性睡眠呼吸暂停低通气综合征及其合并高血压的相关性研究

Correlation between Plasma 8-Iso-Prostaglandin F_(2α) Level and Obstructive Sleep Apnea-Hypopnea Syndrome Its Complicated Hypertension

目的检测血浆8-异前列腺素F2α(8-iso-PGF2α)水平在单纯阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)及OSAHS合并高血压患者中的变化,探讨OSAHS的病理生理变化,OSAHS合并高血压的发病机制。方法选择OSAHS患者19例(OSAHS组)、OSAHS合并高血压患者21例(OS-AHS+HT组),选择同期健康体检者20人作为正常对照组,用酶联免疫吸附法检测3组受检者的血浆8-iso-PGF2α水平,并进行统计学分析。结果对照组、OSAHS组及OSAHS+HT组患者血浆8-iso-PGF2α水平分别为(7.5±2.1)ng/ml、(11.1±3.3)ng/ml和(14.8±3.4)ng/ml,3组比较差异有统计学意义(F=30.992,P<0.01)。OSAHS组及OSAHS+HT组血浆8-iso-PGF2α水平与对照组比较差异均有统计学意义(P<0.01)。相关分析显示:血浆8-iso-PGF2α水平与睡眠呼吸暂停低通气指数(AHI)、SaO2<90%占总睡眠时间百分比、睡眠呼吸障碍事件总时间占总睡眠时间百分比、睡眠呼吸障碍事件时最低SaO2及平均最低SaO2、睡眠呼吸障碍事件最长时间相关(P<0.05)。结论OSAHS患者氧化应激水平升高,并可能是OSAHS发病及OSAHS合并高血压病的原因之一。OSAHS患者血浆8-iso-PGF水平与反映睡眠呼吸暂停严重程度的指标明显相关。

Objective To investigate the changes of plasma 8-iso-prostaglandin F 2α(8-iso-PGF2α)in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)and in those with complicated hypertension(OSAHS+HT),pathophysiological changes of OSAHS,the pathogenesis of OSAHS+HT.Methods Nineteen OSAHS patients (OSAHS group),21 OSAHS patients with complicated hypertension (OSAHS+HT group) and concurrently 20 health persons (control group) were enrolled.The plasma 8-iso-PGF2α in all the subjects were measured by ELISA and the results were compared among the 3 groups.Results The plasma 8-iso-PGF F2αconcentrations were (7.5±2.1)ng/ml in the control group,(11.1±3.3)ng/ml in OSAHS group and (14.8±3.4)ng/ml in OSAHS+HT group.There was a significant difference among the 3 groups (F=30.992,P<0.01),and there was a significant difference between OSAHS,OSAHS+HT groups and control group(P<0.01).The correlation analysis showed that the plasma level of 8-iso-PGF2α in OSAHS and OSAHS+HT groups were significantly correlated with the sleep apnea hypopnea index,percentage of SaO2<90% lasting time over the total sleeping time,ratio of sleep apnea time to total sleep time,lowest SaO2 during sleep apnea,average lowest SaO2,and longest time at apnea event (P<0.05).Conclusion Oxidative stress in OSAHS patients goes up,which may be one of the pathogeneses of OSAHS and its complicated hypertension.The plasma OSAHS 8-iso-PGF F2αis obviously correlated with the indices reflecting the severity of sleep apnea.