补肾生血颗粒对慢性肾衰实验性大鼠血TNF和EPO的作用

Bushen Shengxue Particles Experimental Chronic Renal Failure on Blood TNF And The Role of EPO

[目的]探讨补肾生血颗粒对慢性肾功能衰竭大鼠改善肾性贫血作用及血EPO、TNF的影响。[方法]采用腺嘌呤建立大鼠贫血模型,随机分为模型对照组、中药治疗组(补肾生血颗粒)、西药治疗组(促红素EPO)、中西药联合治疗组(补肾生血颗粒、EPO联用)。测血RBC、Hb、HCT、肾功、EPO及肿瘤坏死因子(TNF)的指标。[结果]与中药组及中西药联合应用组相比,补肾生血颗粒治疗肾性贫血的效果与EPO无明显差异(P>0.05),稍逊于中西药联合应用组(P<0.05),并能明显降低血BUN、Cr的含量(P<0.01),减轻肾组织病理损害,还可降低血TNF,提高血EPO的水平。[结论]补肾生血颗粒能有效治疗肾性贫血并能明显改善肾功能,提高血EPO含量,还有降低血TNF的作用。

[Objective] To investigate the blood particles Bushen chronic renal failure in rats to improve the role of renal anemia and blood EPO, TNF impact. [ Methods ] adenine anemia in rats were randomly divided into model control group, traditional Chinese medicine treatment group ( Bushen Shengxue particles) , western medicine treatment group ( EPO EPO) , in the treatment of western medicine group ( Bushen Shengxue particles, GC EPO). Measurement of blood RBC, Hb, HCT, renal function, EPO and tumor necrosis factor (TNF) indicators. [ Results ] and traditional Chinese medicine and western medicine group combined group, the treatment of kidney blood particle effect of renal anemia with EPO was no significant difference ( P > 0. 05 ) , less in the combination of western medicine group (P <0. 05) ,and can significantly lower blood BUN,Cr content (P <0. 01) ,reduce the pathological damage of renal tissue,can reduce the blood TNF,increase the blood level of EPO. [Conclusion]The blood particles Bushen effective treatment of renal anemia and renal function improved significantly improve the blood content of EPO,as well as to reduce the role of TNF in blood.