摘要
目的探讨白藜芦醇预防小鼠高脂血症形成的作用效果及其分子机制。方法50只普通健康小鼠随机分成:①正常对照组;②高脂对照组;③白藜芦醇低剂量组〔50 mg/(kg.d)〕;④白藜芦醇中剂量组〔100 mg/(kg.d)〕;⑤白藜芦醇高剂量组〔150 mg/(kg.d)〕。白藜芦醇各实验组先普通饲养喂养2周,后转为高脂饲料喂养3周并同时按剂量给药;正常对照组一直普通饲料喂养5周;高脂对照组先普通饲料喂养2周,后转为高脂饲料再喂养3周。实验共观察5周,结束后处死小鼠并检测各组小鼠血清中TG、TC、LDL-C、HDL-C浓度及相关基因LDLR、angptl3 mRNA表达情况。结果①白藜芦醇各实验组可降低小鼠血清中TG、TC及LDL-C浓度,升高HDL-C浓度,与高脂对照组相比,差异有统计学意义(P<0.05);②白藜芦醇各实验组可促进LDLR基因mRNA表达增高,抑制angptl3基因mRNA表达,与高脂对照组相比,差异有统计学意义(P<0.05)。结论白藜芦醇能有效预防小鼠高脂血症的形成,其机制可能与下调angptl3、上调LDLR基因mRNA表达有关。
Objective To explore the effect and the mechanism of resveratrol on formation of hyperlipidemia in mice.Methods Fifty healthy mice were randomly divided into:①the normal control group;②the high lipid control group;③the resveratrol group with low dose(50 mg/(kg·d));④the resveratrol group with middle dose(100 mg/(kg·d));and ⑤the resveratrol group with high dose(150 mg/(kg·d)).All resveratrol groups were fed the common diets for 2 weeks,then turned to be fed the high lipid diets for 3 weeks as well as the resv...
出处
《中国自然医学杂志》
CAS
2009年第3期171-174,共4页
Chinese Journal of Natural Medicine
基金
福建中西医结合研究院陈可冀院士基金资助(CKJ2006002)
关键词
白藜芦醇
小鼠
高脂血症
预防效果
作用机制
Resveratrol
Mouse
Hyperlipidemia
Preventive effect
Molecular mechanism