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Anti-Inflammatory Mechanism of Total Glycosides of Acanthopanax Giraldii 被引量：4

Anti-Inflammatory Mechanism of Total Glycosides of Acanthopanax Giraldii
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摘要 Objective:To study the anti-inflammatory mechanisms of total glycosides of Acanthopanax Giraldii (TGA).Methods:The changes of prostaglandin E_2(PGE_2),tumor necrosis factor(TNF-α),nitric oxide(NO), and expressions of COX-1 mRNA and COX-2 mRNA in BALB/c mouse macrophages were observed by the radioimmunoassay,ELISA and nitric acid reduction and RT-PCR in the presence or absence of TGA.Results: (1) TGA could significantly decrease the production of PGE_2 and NO in mouse peritoneal macrophages.The inhibitory ra... Objective:To study the anti-inflammatory mechanisms of total glycosides of Acanthopanax Giraldii (TGA).Methods:The changes of prostaglandin E_2(PGE_2),tumor necrosis factor(TNF-α),nitric oxide(NO), and expressions of COX-1 mRNA and COX-2 mRNA in BALB/c mouse macrophages were observed by the radioimmunoassay,ELISA and nitric acid reduction and RT-PCR in the presence or absence of TGA.Results: (1) TGA could significantly decrease the production of PGE_2 and NO in mouse peritoneal macrophages.The inhibitory ra...
作者 袁芳 陈杰 许国敏 郑加嘉 龙启才
机构地区 Institute of Clinical Pharmacology School of Pharmaceutical Sciences Department of Pharmacy the First Affiliated Hospital Shenzhen Buji People's Hospital
出处 《Chinese Journal of Integrative Medicine》 SCIE CAS 2009年第3期210-215,共6页 中国结合医学杂志（英文版）
关键词 total glycosides of Acanthopanax Giraldii prostaglandin E_2 nitric oxide tumor necrosis factor COX mRNA total glycosides of Acanthopanax Giraldii prostaglandin E_2 nitric oxide tumor necrosis factor COX mRNA
分类号 R285.5 [医药卫生—中药学]
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  • 1SanghyunLee,Hyun SeungBan,Yong PilKim,Bak‐KwangKim,Seon HaengCho,KazuoOhuchi,Kuk HyunShin.Lignans from Acanthopanax chiisanensis having an inhibitory activity on prostaglandin E<sub>2</sub> production[J].Phytother Res.2005(2)
  • 2Hyun Seung Ban,Sanghyun Lee,Yong Pil Kim,Kouya Yamaki,Kuk Hyun Shin,Kazuo Ohuchi.Inhibition of prostaglandin E 2 production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action[J].Biochemical Pharmacology.2002(9)
  • 3Pharmacopeia Committee of P.R.China.Pharmacopoeia of People’’s Republic of China[]..2010
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  • 8Won Jong-Heon,Park Sang-Yong,Nam Sang-Gil,Park Hee-Juhn,Choi Jong-Won,Lee Kyung-Tae.Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells[].Biological and Pharmaceutical Bulletin.2005
  • 9Kim Jong-Hwan,Park Young-Mi,Shin Ji-Sun,Park Seung Jae,Choi Jung-Hye,Jung Hyun-Ju,Park Hee-Juhn,Lee Kyung-Tae.Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells[].Biological and Pharmaceutical Bulletin.2009
  • 10Nhiem Nguyen Xuan,Tung Nguyen Huu,Kiem Phan Van,Minh Chau Van,Ding Yan,Hyun Jae-Hee,Kang Hee-Kyoung,Kim Young Ho.Lupane triterpene glycosides from leave of Acanthopanax koreanum and their cytotoxic activity[].Chemical & pharmaceutical bulletin.2009

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Chinese Journal of Integrative Medicine
2009年 第3期

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