吸烟对口腔鳞状上皮细胞膜表面结构的影响

The effect of smoking on oral squamous cell membrane surface

应用原子力显微镜(AFM)对无吸烟史的健康人、中度吸烟组、重度吸烟组、口腔鳞状上皮不典型增生组、口腔鳞状细胞癌组的口腔鳞状上皮细胞膜超微结构进行观察,并应用图像软件分析细胞膜表面的平均粗糙度、峰值、表面积差值,以探讨吸烟对口腔鳞状上皮细胞膜超微结构的影响机制,寻找预测口腔癌发生的早期检测指标。结果表明:随着吸烟指数的增加,细胞外形逐渐不规则,癌细胞异型性较大;细胞膜表面平均粗糙度、峰值、表面积差值呈增大趋势。证明吸烟影响口腔鳞状上皮细胞膜超微结构。

Atomic force microscope(AFM) was used in scanning cell membrane supermicro structure of oral squamous cell membrane of the healthy group having nosmoking,group of moderate smokers,group of heavy smokers,group of oral squamous epithelium atypical hyperplasia and oral squamous cell carcinoma group.Analysis system of AFM was applied to measure and analyze statistics of an average roughness(mean roughness),the peak(peak count) and the surface area difference(surface area difference),to confer the effect of smok...