摘要
目的研究血清中丝氨酸蛋白酶抑制剂-2(SERPINE2)基因多态性与慢性阻塞性肺疾病(COPD)表型的相关性,探索COPD的发病机制。方法选取100例COPD散发患者作为病例组,同时选100例健康者作为对照组,通过等位基因特异性探针检测血清单核苷酸多态性(SNP),判定单个样本的基因型并进行χ2检验和相关分析。结果rs6734100位点的突变与COPD不存在相关性。结论SERPINE2不是汉族人COPD患者的易感基因。
Objective To explore the relationship between SERPINE2 polymorphisms and chronic obstructive pulmonary disease(COPD)-related phenotypes and to investigate the mechanism of COPD.Methods 100 patients with COPD served as the experimental group and 100 healthy people as the control group.In the present study,we genotyped the single nucleotide polymorphisms(SNPs) from SERPINE2 by special allele multiprobe technology and identified its gene type.The case-control data were analyzed using a chi-square test and corr...
出处
《山东大学学报（医学版）》
CAS
北大核心
2009年第7期111-114,共4页
Journal of Shandong University:Health Sciences
关键词
肺疾病
慢性阻塞性
丝氨酸蛋白酶抑制剂
多态性
单核苷酸
Pulmonary disease
chronic obstructive
Serine proteinase inhibitors
Polymorphism
single nucleotide
