新型α-乙酯基芳亚甲基膦亚胺中间体的合成

Synthesis of Novel Intermediate α-Ethoxycarbonylarylmethylideneiminophosphoranes

研究了应用氯乙酸乙酯1和叠氮化钠的亲核取代反应产物α-叠氮基乙酸乙酯2与芳醛的缩合反应制取α-叠氮基芳亚甲基乙酸乙酯3,再与三苯基膦的Staudinger反应,来合成α-乙酯基芳亚甲基膦亚胺中间体4的方法,探讨了缩合反应和Staudinger反应进行的条件,用元素分析、IR和1HNMR对目标产物进行了结构表征.

α-Azidoacetic ester 2, prepared via chloroacetic ester 1 and sodium azide, and aromatic aldehydes were condensed into α-azidoarylmethylideneacetic ester 3, and α-ethoxycarbonylarylmethylideneiminophosphoranes 4 were synthesized via Staudinger reaction of 3 and triphenylphosphine. The condition for condensation and Staudinger reactions was researched. The structures of the compounds4 were characterized by elemental analysis, IR and1H NMR.