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THE EXPRESSION AND CLINICAL SIGNIFICANCE OF P21(WAF1/CIP1) AND CYCLIN D1 PROTEIN IN COLORECTAL CARCINOMA

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF P21(WAF1/CIP1) AND CYCLIN D1 PROTEIN IN COLORECTAL CARCINOMA
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摘要 Objective To study the effect of P21(WAF1/CIP1) and cyclin D1 and their relationship in colorectal carcinoma.Methods The expression of P21 and cyclin D1 was studied in 40 colorectal carcinoma and 10 normal tissues using S P immunohistochemical technique.Results Decreased expression of P12 and overexpression of cyclin D1 were revealed in colorectal carcinoma.Decreased expression of P21 was related to lymph node metastasis.No correlation was found between cyclin D1 and clinicopathological parameters.Conclusion Decreased expression of P21 and overexpression of cyclin D1 may be involved in colorectal tumorigenesis,and were associated with poor prognosis.No correlation was found between P21 and cyclin D1 in colorectal carcinoma. Objective To study the effect of P21(WAF1/CIP1) and cyclin D1 and their relationship in colorectal carcinoma.Methods The expression of P21 and cyclin D1 was studied in 40 colorectal carcinoma and 10 normal tissues using S P immunohistochemical technique.Results Decreased expression of P12 and overexpression of cyclin D1 were revealed in colorectal carcinoma.Decreased expression of P21 was related to lymph node metastasis.No correlation was found between cyclin D1 and clinicopathological parameters.Conclusion Decreased expression of P21 and overexpression of cyclin D1 may be involved in colorectal tumorigenesis,and were associated with poor prognosis.No correlation was found between P21 and cyclin D1 in colorectal carcinoma.
作者 雷联会 许延发 盛薇
出处 《Academic Journal of Xi'an Jiaotong University》 2000年第2期160-162,167,共4页 西安交通大学学报（英文版）
关键词 colorectal carcinoma P21(WAF1/CIP1) cyclin D1 IMMUNOHISTOCHEMISTRY prognosisp colorectal carcinoma P21(WAF1/CIP1) cyclin D1 immunohistochemistry prognosisp
分类号 U [交通运输工程]
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参考文献16

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Academic Journal of Xi'an Jiaotong University
2000年 第2期

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