咪唑安定在机械通气中人机拮抗时的应用

Application of Midazolam in Fight the Ventilator of Mechanical Ventilation

目的:观察咪唑安定在机械通气中改善人机拮抗的临床疗效。方法:2000年11月至2001年12月对机械通气时出现人机拮抗的126例应用咪唑安定治疗,观察咪唑安定应用前、后患者动脉血气分析指标中pH、PaO_2、PaCO_2、SatO_2及通气状态的变化,采用自身对照t检验进行分析,P<0.05有显著统计学意义。结果:应用咪唑安定后,患者pH、PaO_2、SatO_2均有明显改善(P<0.001),通气状态好转,而PaCO_2无显著性差异。结论:咪唑安定对机械通气中的人机拮抗有较好疗效,可改善病人的通气状况。

Objective: To observe the clinical effect of midazolam to deal with the fight the ventilator in mechanical ventilation. Methods: Monitoring the pH, Pa0_2, PaC0_2, Sat0_2 and ventilation state before and after midazolam injected. Applying oneself-control t test to analyze the data and selecting P<0.05 significant difference. Results: pH, Pa0_2, SatO_2 and ventilation of patient significant ameliorate after midazolam injected, but PaCO_2 no significant change. Conclusions: Midazolam can deal with the fight the ventilator and approve the ventilation of the patient.