尼莫通在急性脑卒中患者中的降压作用及安全性

Assessment of Intravenous Nimoton Therapy in Hypertension of Acute Stroke

目的:观察尼莫通静脉滴注对急性脑卒中患者的高血压的降压作用及安全性。方法:选择急性脑卒中46例,患者经脱水、镇静等常规治疗后仍有血压明显升高,治疗前平均收缩压(SBP)≥225mmHg(1mmHg=0.133kPa)和/或舒张压(DBP)≥120mmHg。以恒速输液泵持续静脉滴注尼莫通,初始剂量3ml/小时,根据血压调整输液速度,直至达到目标血压170～180/100～110mmHg后维持静滴24小时。结果:用药后30min、60min、2hr、3hr的平均血压降至218/115mmHg、205/110mmHg、198/108mmHg,188/105mmHg,4小时后达最大效应,血压为175/100mmHg,并稳定至用药结束时的173/98mmHg,未发现严重不良反应。结论:尼莫通静脉滴注对急性脑卒中患者的高血压有明显的降压作用,降压作用平稳,安全性高。

Objective: To assess the efficacy and safety of intravenous Nimoton in hypertension of acute stroke. Methods: 46 patients with acute stroke whose systolic blood pressure(SBP) ≥225 mmHg and/or diastolic blood pressure (DBP) ≥120 mmHg were treated with continual intravenous Nimoton by stable velocity pump at the velocity of 3 ml/h at the beginning. The velocity of intravenous Nimoton was adjusted according to the patients' blood pressure(BP), till an optimal BP(170～180/100～110 mmHg) accurred. Then, keep the optimal dosage 24 hours. Results: 30 min, 60 min, 2 hr, 3 hr after the therapy, the mean blood pressure(MBP) droped respectively to 218/115 mmHg、205/110 mmHg、198/108 mmHg, 188/105 mmHg. When top efficacy accurred at 4 hr after the therapy, BP was 175/100 mmHg, which was kept stablly to the end. Not any side effect was detected. Conclusions: Intravenous Nimoton therapy was effective and safe in hypertension of acute stroke.