利多卡因治疗重症新生儿破伤风疗效观察

Observation of the Effect of Lidocaine Treatment on Severe Neonatal Tetanus

目的:探讨利多卡因对重症新生儿破伤风的治疗效果。方法:按照单盲、随机、对照的研究方法,对49例重症破伤风的新生儿随机分为治疗组21例,对照组28例,其中对照组采用常规治疗方案,治疗组在常规治疗方法的基础上加用利多卡因治疗,观察疗效及安全性。结果:治疗组总有效率为95.24％,与对照组总有效率67.86％比较,差异有显著性(P<0.05)。结论:利多卡因的止痉作用显著,对重症新生儿破伤风的持续性抽搐有较好的疗效,安全性高。

Objective: To discuss the effect of lidocaine treatment on the severe neonatal tetanus. Methods: Using the methods of single blind, random, and controlled group, 49 cases of severe neonatal tetanus were divided randomly into a treatment group with 21 cases, and a controlled group with 28 cases. The controlled group was treated with conventional ways, while the treatment group were treated with lidocaine in addition to the conventional way. The effect and security were observed. Results: The overall efficiency of the treatment group was 95.24%, compared with 67.86% of the controlled group, there was a significant difference(P<0.05). Conclusions: Lidocaine had a significant trangulizing effect on the center, and a better effect with high security on persistent tic in the severe neonatal tetanus.