奥拉西坦注射液对急性脑梗死患者的疗效观察

Treatment of Acute Cerebral Infarction with Oxiracetam Injection

目的观察奥拉西坦治疗急性脑梗死的效果。方法将80例急性脑梗死患者分为两组:治疗组和对照组各40例,治疗组除基础治疗外,加用奥拉西坦注射液4.0g入5%葡萄糖或生理盐水中,每日一次静滴;对照组仅采用常规抗血小板聚集、营养神经,改善微循环等常规治疗,必要时抗凝和对症治疗。一疗程后比较两组显效率、总有效率、神经功能缺损评分及日常生活活动能力评分。结果治疗组和对照组显效率分别为52.50%和35%(P<0.05),总有效率分别为77.50%和55%(P<0.05);与对照组比较,治疗组神经功能缺损评分明显减少(P<0.05),患者日常生活能力明显提高(P<0.05)。结论奥拉西坦有明显地改善急性脑梗死临床神经功能、提高患者日常生活能力的作用。

Objective To investigate effect of oxiracetam on treatment of acute cerebral infarction,Methods Eighty patients with acute cerebral infarction were randomly divided into two groups:the treatment group(40 cases) and the control group(40 cases),The treatment group was given oxiracetam injection of 4.0 g in 5% glucose or nor- mal saline, intravenously once a clay, besides other conventional treatment;the control group was only given conven- tional treatment, e.g,anti-platelet aggregation, nerve nutrition, improvement of mierocireulation, and so on,If nec- essary, anticoagulation and symptomatic treatment were used,After a course of treatment, excellent effective rate and overall effective rate, neurological deficit scores, and the scores of activities of daily life were compared with one an- other,Results Excellent effective rate in the treatment group and the control group were respectively 52.50% and 35%(P<0.05)and the overall effective rate were 77.50% and 55%(P<0.05),Compared with the control group, the scores of neurologie impairment of the treatment group reduced(P<0.05), meanwhile the scores of activities of daily life increased significantly(P<0.05),Conclusion Oxiracetam can significantly neurological function of acute cerebral infarction and the ability of patients in daily life.