注意缺陷多动障碍患儿的P 300检测

Detection of P 300 in children with Attention Deficit and Hyperactivity Disorder

目的探讨注意缺陷多动障碍(ADHD)患儿事件相关电位 P 300指标及其治疗前后的特点。方法应用美国 NicoletSpirit 脑诱发电位仪,记录36例 ADHD 患儿和32名正常儿童(NC 组)的 P 300,对其中33例 ADHD 患儿于治疗6个月后再次检测 P 300。结果 (1)ADHD 组 P 300-N_2和 P_3靶潜伏期长于 NC 组,P 300-P_3靶波幅低于 NC 组(P<0.01)。(2)利太林治疗后,ADHD 组随多动症状改善,脑诱发电位中 P 300-N_2靶潜伏期缩短[治疗前后分别为(273±20)ms 和(260±17)ms,P<0.01],P_3靶波幅升高[分别为(2.9±1.9)μV和(4.6±2.0)μV,P<0.01]。结论 ADHD 患儿 P 300有变化,治疗后随着多动症状的改善,与认知功能有关的 P 300指标也有相应改善。

Objective To assess the characteristics of event-related potential P 300 of patients with attention def- icit and hyperactivity disorder(ADHD)before and after treatment,Methods There were 36 ADHD patients and 32 normal controls in this study,Event-related potential P 300 was recorded using an American Nicolet Spirit Instru- ment,And 33 ADHD patients were followed up after 6 months with the same markers,Results Compared with NC, ADHD patients showed significantly prolonged N_2/P 300 and P_3/P 300 latencies and decreased P_3/P 300 ampli- tudes(P<0.01),Compared with previous treatment, after methylphenidate treatment ADHD patients had shortened N_2/P_300 latency [before:(273±20)ms, after:(260±17)ms, P<0.01]and increased P3 amplitude[before: (2.9±1.9)μv, after:(4.6±2.0)μv, P<0.01],Conclusion There is a change in the P300 in ADHD children,After treatment, hyperactivity disorder has been improved and P 300 related to cognitive function has also been improved.