小剂量阿司匹林在动脉粥样硬化中的抗炎作用

The Action of Anti-inflammation of Low-dose Aspirin in Atherosclerotic Disease

小剂量阿司匹林通过抑制血小板内环氧化酶-1(COX-1)的活性,阻止血栓素A2的产生而发挥抗血栓作用,进而预防缺血性心脑血管疾病如心肌梗死及脑梗死的发生。研究提示,小剂量阿司匹林除了抗血小板活性外,还有其他的功能,如抗炎作用。本文重点探讨小剂量阿司匹林在动脉粥样硬化中的抗炎作用。

Low-dose aspirin aspirin exerts anti-thrombotic action by acetylating and inactivating cyclooxygenase-1,preventing the production of thromboxane A2 in platelets,therefore low-dose aspirin is considered as a preventative of ischemic diseases such as myocardial and cerebral infarction. However,many studies have revealed that aspirin has other beneficial actions in addition to its antiplatelet activity. In this review,we discuss the involvement of inflammation in atherosclerosis and how Low-dose aspirin aspirin exerts its anti-inflammation action in atherosclerotic diseases.