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纳米粒子的靶向作用机制研究进展 被引量：4

Progress in the mechanism of targeting of nanoparticles
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摘要 　　纳米粒子是指尺度在1 ～ 100nm 之间的微粒[1],这类粒子具有量子尺寸效应、小尺寸效应、表面与界面效应与协同效应等性质,表现为比表面积大、表面活性中心多、表面反应活性高、吸附能力强、催化能力高、毒性低及不易被体内和细胞内各种酶降解等.纳米粒子载药不仅可以提高药物对癌组织的靶向性,还可以高选择性地作用于癌细胞内外的小分子或基因物质,对原发恶性肿瘤和转移性恶性肿瘤都有很好的疗效[2-4].……
作者 赵君贤 张英鸽
机构地区 军事医学科学院毒物药物研究所纳米药理毒理学重点实验室
出处 《中国医药生物技术》 CSCD 2007年第5期370-372,共3页 Chinese Medicinal Biotechnology
基金 国家高技术研究发展计划(863计划)(2006AA03Z333) 国家重点基础研究计划(973计划)(2006CB933304)
关键词 纳米粒子 肿瘤细胞 碳水化合物 凝集素 抗肿瘤药物 靶向作用 药物递送系统
分类号 R318.08 [医药卫生—生物医学工程]
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参考文献21

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同被引文献27

  • 1梅林,孙洪范,宋存先.紫杉醇制剂研究进展[J].中国药学杂志,2006,41(18):1366-1370. 被引量：16
  • 2王培林,傅松滨.医学遗传学[M].第3版,北京:科学出版社,2011:108-153.
  • 3LU J Q,HUANG Y X,ZHAO W C,et al.PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel tobreast and prostate cancers[J].Biornaterials,2013,34:1591-1600.
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  • 5Wang Y, Lee AT, Ma JZ, et al. Profiling microRNA expression inhepatocellular carcinoma reveals microRNA-224 Up-regulation andapoptosis inhibitor-5 as a microRNA-224-specific target [ J ]. J BiolChem,2008,283(19) : 13205-13215.
  • 6Zhang Y,Takahashi S,Tasaka A,et al. Involvement of microRNA-224 in cell proliferation,migration,invasion,and anti-apoptosis inhepatocellular carcinoma [ J ]. J Gastroenterol Hepatol,2013,28(3):565-575.
  • 7in hepatocellular carcinoma through epigenetic mechanisms [ J ].FASEB J, 2012, 26(7) :3032-3041.
  • 8Aghajanian C,Soignet S, Dizon DS. A phase I trial of the novelproteasome inhibitor PS34 1 in advanced solid tumor malignancies[J]. Clin Cancer Res ,2002 ,8 ( 8) :2505-2511.
  • 9Rigou P, Piddubnyak V,Faye A, et al. The antiapoptotic proteinAAC-11 interacts with and regulates Acinus-mediated DNAfragmentation[J]. EMBO J,2009, 28(11 ):1576-1588.
  • 10Yu Wang,Han Chong Toh,Pierce Chow,Alexander Y. F. Chung,David J. Meyers,Philip A. Cole,London L. P. J. Ooi,Caroline G. L. Lee.MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms[J]. The FASEB Journal . 2012 (7)

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中国医药生物技术
2007年 第5期

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