1[1]Goodacre R.Making sense of the metabolome using evolutionary computation:seeing the wood with the trees.J Exp Bot,2004,0:431
2[2]Nicholson JK,Timbrell JA,Sadler PJ.Proton NMR spectra of uric as indicators of renal damage::mercury nephrotoxicity in rats.Mo Pharamacol,1985,27:644.
4[4]Griffin J L.Metabonomics:NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis[J].Curr Opin Chem Biol,2003,7(5):648-654
5[5]Criffin J L.The potential of metabonomics in drug safety and toxicology[J].Jrug Discov Today:Technologies,2004,1(3):285-293.
8[8]Wang Q,Jiang Y,Wu C,Zhao J.Study of a novel indolin-2-ketone compound Z24 induced hepatotoxicity by NMR-spectroscopy-based metabonomics of rat urine,blood plasma,and liver extra[J].Toxicol Appl Pharmacol.2006,215(1):71-82.
9[9]Gavaghan CL,Holmes E,Len Z E,et al.An NMR-based metabonomic apprcach to investigate the biochemical comsequences of genetic strain differenees:application to the C57BL10J and Alpk:ApfCD mouse[J].FEBS Lett,2000,484(3):169-174.
10[10]Brindle JT,Antti H,Holmes E.Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics[J].Nat Med.2002 8(12):1439-44.
2Hellmold H, Nilsson CB, Schuppe-Koistinen I et al. Identification of end points relevant to detection of potentially adverse drug reactions. Toxicology Letters, 2002, 127:239.
3Aranbar N, Singh BK, Stockton GW et al. Automated mode-of-Action detection by metabolic profiling. Biochem Biophys Res Commun, 2001, 286: 150- 155.
7Smith LL. Key challenges for toxicologists in the 21st century .Trends Pharmacol Sci, 2001, 22:281 - 285.
8Stafford DE, Stephanopoulos G. Metabolic engineering as an integrating platform for strain development. Ecology amt Industrial Microbiology, 2003. 336- 340.
9Harrigan G. Metabolic profiling: pathways in drug discovery. Drug Discovery Today, 2003, 7: 351- 352.
10Schwab W. Metabolome diversity: too few genes, too many metabolites? Phytochemistry, 2003, 62: 837- 849.