前列腺素E1对老年闭塞性周围动脉粥样硬化患者血小板功能的影响

Influence of PGE1 on the function of blood platelet in the elder PAOD patients

目的观察前列腺素E1(PGE1)对老年闭塞性周围动脉粥样硬化(PAOD)患者血小板功能的影响。方法选择FontaineⅡ～Ⅲ级PAOD患者60例,观察应用PGE1前后患者血浆血小板膜α颗粒糖蛋白-140(GMP-140)、前列环素1α(6-k-PGFlα)、血栓素B2(TXB2)的变化。结果治疗后FontaineⅡ级及Ⅲ级患者疗效分别为显效11.1%,16.7%,有效61.1l%,52.38%,无效27.78%,30.95%,总有效率72.22%,69.05%;治疗前后血常规、凝血功能、肝肾功能、血糖、血脂检查结果均无明显变化(P>0.05),而GMP-140、6-k-PGFlα、TXB2较治疗前改变明显(P<0.05)。结论PGE1可以改善血小板功能,对老年PAOD患者安全有效,值得临床推广。

Objective To observe the influence of PGE1 on the function of blood platelet in the elder PAOD patients; Methods 60 elder patients of Fontaine Ⅱ～Ⅲ level being in hospital were observed the change of plasma GMP-140,6-k-PGF1α,TXB2 by use PGE1. Results After the treatment, the curative effect of Fontaine II～III level of patients were shows result 11.1%, 16.7%, effective 61.11%, 52.38%, invalid 27.78%, 30.95%, total effectiveness 72.22%, 69.05%; Around treatment, the results of blood RT, hemoglutination function, hepatic and renal function, blood sugar and blood fats has no obvious change(P>0.05), but GMP-140,6-k-PGFlα and TXB2 has the obvious change (P<0.05). Conclusions PGE1 may improve function of blood platelet, safe and effective to the elder PAOD patients, is worth the clinical promotion.