核糖体蛋白基因转录起始位点附近碱基信息分析

Analysis of Base Information Round the TSS of Ribosomal Protein Genes

对核糖体蛋白基因和其它基因的转录起始位点附近序列的单个和双碱基的使用频率进行统计分析,抽提出核糖体蛋白基因中富含的元素;利用层次分析法计算出核糖体蛋白基因单个和双碱基在转录起始位点附近出现频率的位置权重,进而得出可能有利于核糖体蛋白基因转录的元素.

It has been demonstrated that there was a long difference of the sequence features between highly and lowly transcribed yeast genes.And by the research of the sequence features and the mechanism of transcription regulation of the highly transcribed genes,nearly all the protein coded by highly transcribed genes we obtained are ribosomal protein.The results indicate that further research on the related information of ribosomal protein genes may help us to reveal the features of highly transcribed yeast genes and explain the mechanism of transcription regulation of genes.Through the observation we find a phenomenon that there are characters which are quite different from other genes or they have their own characters round the TSS of ribosomal protein genes.Based on the statistical comparative analysis on the occurrence frequencies of single base and double bases round the TSS of ribosomal protein genes and other genes,some abundant elements were extracted in the ribosomal protein genes.And the position weight of the occurrence frequency of single base and double bases of ribosomal protein genes round the TSS were worked out by the analytic hierarchy process.Furthermore,we got the elements could help the ribosomal protein genes to transcribe.