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肌萎缩侧索硬化的临床研究进展

Clinical research progress of amyotrophic lateral sclerosis
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摘要 　　肌萎缩侧索硬化(ALS)是一类累及上、下运动神经元的慢性变性疾病.本病于1869年由Charcot首次报道.作为运动神经元病(MND)的代表疾病,肌萎缩侧索硬化(ALS)为全球分布,该病的平均发病年龄在59岁,并非这一年龄组独有,低龄成人也可罹患此病,尤其是有肌萎缩侧索硬化家族史者[1].本病患者男性多于女性,比率约为3∶2,性别差异的原因不明[2].ALS的年发病率约为每1O万人口1～3人,患病率约为每1O万人口5～9人[3],是成年人最常见的导致瘫痪的疾病之一.从症状发作至死亡平均存活时间为3～5年,5年存活率约25% [4].……
作者 贾怡蓓 刘学源
机构地区 上海市第十人民医院神经内科
出处 《神经病学与神经康复学杂志》 2007年第1期46-48,共3页 Journal of Neurology and Neurorehabilitation
分类号 R [医药卫生]
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参考文献28

  • 1[1]Zhang H,Zhao H,Lu M,et al.A rare Cu/Zn superoxide dismutasemutation causing familial amyotrophic lateral sclerosis with variable age of onset and incomplete penetrance in China[J].ALS Other MND,2005,6:in press.
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  • 10王惠芳,樊东升,张俊,张华纲,王晓飞,鲁明,康德宣.肌萎缩侧索硬化症的院前误诊分析[J].中国现代神经疾病杂志,2005,5(4):240-243. 被引量：13

二级参考文献75

  • 1康德瑄,樊东升.胸锁乳突肌肌电图在鉴别肌萎缩侧索硬化与颈椎病性脊髓病的研究[J].中国神经精神疾病杂志,1994,20(1):5-7. 被引量：47
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神经病学与神经康复学杂志
2007年 第1期

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