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5-羟色胺转运体基因多态性与抑郁症病因及疗效的研究现状 被引量：1

Current Status of Relationship of Serotonin Transporter Gene-linked Polymorphic Region(5-HTTLPR) and Etiology and Therapeutic Effect of Depression
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摘要 随着我国进入老龄化社会,卒中的发病率逐年升高,卒中患者的生活质量越来越受到关注。卒中后抑郁的发生在很大程度上影响了患者的生活质量和躯体疾病的恢复。回顾我们对卒中后情绪障碍的认识过程,经历了一个从生物医学模式到生物-心理-社会医学模式的转变历程。今天我们更有理由在关注躯体疾病的同时,更多地关注情绪障碍对患者造成的影响,并做出最有利于患者的临床决策。目前国内外学者关于卒中后抑郁发病机制和治疗方面的研究仍处在起步阶段,遗传药理学方面的研究涉及更少。本刊特约多位专家分别从卒中后抑郁的基础研究及临床应用等多个角度,多方位地对卒中后抑郁进行了探讨,期望有助于神经科医生从更科学的角度来认识卒中后抑郁。
作者 徐利敏 潘小平 蒋少艾 邹卿 郭爱华
机构地区 广州医学院附属广州市第一人民医院脑系内科
出处 《中国卒中杂志》 2008年第9期672-676,共5页 Chinese Journal of Stroke
关键词 抑郁症 5-羟色胺转运体 基因多态性 疗效
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献27

  • 1[1]Steimer W,Muller B,Leueht S,et al.Pharmacogenetics a new diagnostic tool in the management of antidepressive drug therapy[J].Clin Chim Acta,2001,308:33-41.
  • 2[2]Lotrich FE,Pollock BO.Meta-analysis of serotonin transporter polymorphisms and affective disorders[J].Psychiatr Genet,2004,14:121-129.
  • 3兑立栋,谭庆荣,张凤刚,张瑞国,郭立,张雅红.抑郁症易感性与5-羟色胺转运体基因的多态性[J].中国临床康复,2005,9(20):140-141. 被引量：5
  • 4[4]Cervilla JA,Rivera M,Molina E,et al.The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4)increases the risk for depression in a large cohort of primary care attendees:the PREDICT-gene study[J].Am J Med Genet B Neuropsyehiatr Genet,2006,141:912-917.
  • 5[5]Minov C,Baghai TC,Schule C,et al.Serotonin-2A-receptor and transporter polymorphisms lack of association in patients with major depression[J].Neurosci Lett,2001,303:119-122.
  • 6肖红,姚辉,郭苏婉,李箕君.中国人群5-羟色胺转运蛋白基因多态性与抑郁症及5-羟色胺摄取抑制剂类抗抑郁药治疗效果的关系(英文)[J].中国临床康复,2006,10(22):187-189. 被引量：7
  • 7杨杨,高成阁,于学文.5-HTTLPR多态性与抑郁症及其临床特征的相关性[J].西安交通大学学报（医学版）,2007,28(1):18-20. 被引量：15
  • 8[8]Rausch JL,Johnson ME,Fei YJ,et al.Initial conditions of serotonin transporter kinetics and genOtype:influence on SSRI treatment trial outcome[J].Biol Psychiatry,2002,51:723-732.
  • 9[9]Pollock BG,Ferrell RE,Mulsant BH,et al.Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depession[J].Neuropsychopharmacology,2000,23:587-590.
  • 10[10]Arias B,Catalan R,Gasto C,et al.5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients teated with eitalopram in a 12-weeks follow up study[J].J Clin Psychopharmacol,2003,23:563-567.

二级参考文献43

  • 1Heils A,Teufel A,Petri S, et al.Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene.J Neural Transm Gen Sect 1995;102(3):247-54
  • 2Heils A, Mossner R, Lesch KP.The human serotonin transporter gene polymorphism-basic research and clinical implications.J Neural Transm 1997;104(10):1005-14
  • 3Rausch JL,Johnson ME,Fei YJ,et al.Initial conditions of serotonin transporter kinetics and genotype: influence on ssri treatment trial outcome. Biol Psychiatry2002;51 (9):723-32
  • 4Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274(5292):1527-31
  • 5Collier DA, Stober G, Li T,et al.A novel functional polymorphism within the promoter of the serotonin transporter gene:possible role in susceptibility to affective disorders.Mol Psychiatry 1996;1(6):453-60
  • 6Bellivier F, Henry C,Szoke A,et al. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 1998;255(3):143-6
  • 7Caspi A,Sugden K,Moffitt TE,et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Scien1ce 2003;301(5631):386-9
  • 8Joiner TE Jr,Johnson F,Soderstrom K,et al.Is there an association between serotonin transporter gene polymorphism and family history of depression?J Affect Disord 2003;77(3):273-5
  • 9Ewald H,Flint T,Degn B,et al.A functional variant of the serotonin transporter gene in families with bipolar affective disorder.J Affect Disord 1998;48(2-3):135-44
  • 10Mendlewicz J,Massat I,Souery D,et al. Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. Eur J Hum Genet 2004;12(5):377-82

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中国卒中杂志
2008年 第9期

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