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阿托伐他汀对急性脑梗死患者血清基质金属蛋白酶9及预后的影响 被引量:4

Effect of Atorvastatin on Serum Matrix Metalloproteinase-9 (MMP-9) and Prognosis in Patients with Cerebral Infarction
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摘要 目的研究短期应用阿托伐他汀后急性脑梗死患者血清基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)及血脂水平的变化,探讨其对急性脑梗死患者预后的影响。方法采用随机、双盲、安慰剂对照的研究方法,将发病48h内入院的大面积脑梗死患者40例随机分为对照组和阿托伐他汀组(阿托伐他汀20mg/d,连续用药14d)。治疗前后检测血清MMP-9、血脂、血清谷草转氨酶(AST)及血清肌酸激酶(CK)水平,应用美国国立卫生研究院卒中量表(NIHSS)及Barthel指数(BI)记分法对入院后当天及3个月时神经功能缺损程度进行评分。结果共39例进入结果分析(对照组20例,阿托伐他汀组19例)。全部患者治疗前MMP-9水平与入院时及3个月时病情显著相关(P<0.01),血脂水平则无此相关性。治疗后阿托伐他汀组MMP-9水平下降,且与对照组相比,差异有统计学意义(P<0.05)。各组3个月后神经功能缺失程度评分与入院时相比,差异有统计学意义(P<0.01),但两组之间相比无统计学差异。治疗后各组AST及CK水平无明显变化。结论急性脑梗死患者血清MMP-9水平与病情的严重程度及预后相关。短期应用阿托伐他汀可以降低急性脑梗死患者血清MMP-9水平,且安全性好,但对梗死后3个月的预后无明显改善作用。 Objective To study the changes of serum matrix metalloproteinase-9 level and blood lipids level in patients with acute cerebral infarction after short treatment with atorvastatin, and study the effect of atorvastatin prognosis. Methods All 40 acute cerebral infarction patients were divided by random, double-blind, placebo contrasstive method into control group and atorvastain group (20mg/d of atorvastain for 7 days). The serum levels of MMP-9, lipids, aspartate aminotransferase(AST) and creatine kinase(CK) were detected before and after treatment. All patients’ neurological function were evaluated by the National Institutes of Health Stroke Scale (NIHSS) score and the Barthel Index (BI) score at admission and 3 months after admission. Results 39 cases were involved in the study(control group=20, atorvastain group =19).The levels of serum MMP-9 were correlated significantly with severity and prognosis of cerebral infarction(P<0.01), but serum lipids were not correlated. The levels of serum MMP-9 in atorvastain group significantly decreased compared with those in control group(P<0.05). Deficit scales were improved at 3 months after treatment(P<0.01), but there were no statistical difference between atorvastain group and control group . AST and CK levels had no changes after treatment. Conclusion The levels of serum MMP-9 are associated with severity and can predict prognosis of acute cerebral infarction. Short treatment with atorvastain can rapidly and safely reduce the serum level of MMP-9, but there is no signifi cant improvement in 3-month prognosis after cerebral infarction.
出处 《中国卒中杂志》 2008年第11期814-818,共5页 Chinese Journal of Stroke
关键词 脑梗死 阿托伐他汀 基质金属蛋白酶9 Cerebral infarction Matrix metalloproteinase-9 Atorvastain
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参考文献16

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