安徽地区一起恙虫病暴发流行的调查分析

Epidemiological investigation on an outbreak of tsutsugamushi disease in Anhui province

目的对安徽滁州地区一起新发恙虫病暴发流行进行调查分析,以了解其流行病学特点和临床发病情况。方法应用《恙虫病个案调查表》对病例进行流行病学调查,采用胶体金免疫色谱法检测患者血清中的恙虫病东方体抗体IgG和IgM和通过外斐反应检测患者血清中的特异抗体进行诊断。结果2007年11月某部在安徽滁州地区野外训练作业后陆续出现恙虫病病例19例。所有患者发病前均有在该地区野外作业史,临床主要表现为发热、头痛、皮肤焦痂、淋巴结肿大和脾肿大等,并发症较轻,经正确使用强力霉素治疗均有效缓解。结论该地区出现恙虫病暴发流行尚属首次报道。为针对性的预防和控制该地区恙虫病的发生和流行、保障野外训练和作业的安全和战斗力提供了依据。强力霉素是治疗恙虫病的有效药物。

Objective To analyze the epidemiological and clinical characteristics of an new outbreak of tsutsugamushi disease in Chuzhou region of Anhui province.Methods Epidemiological information was collected by case investigation questionnaire of tsutsugamushi disease.Diagnosis was determined by the detection of anti-R.tsutsugamushi antibodies IgM and IgG by colloidal gold immunochromatographic assay(CIA) and OXK antigen by Weil-Felix test.Results Nineteen cases with tsutsugamushi disease outbreaked in November 2007 in the open county of Chuzhou region of Anhui Province after training.All the patients had an experience of working in this area before the starting of symptoms.The clinical features of the patients were fever,headache,skin eschar,lymphadenectasis and splenomegaly.No severe complications occurred in each patient.All the patients recovered after getting deoxycycline.Conclusions This was the first report for the tsutsugamushi disease occured in northern region of Anhui Province.And the declaration for the new-happened tsutsugamushi disease would provide strong-support evidence for the prevention and controls of this event and ensure the safety for working and training in this area.Also the deoxycycline was very effective for the treatment of tsutsugamushi disease.